Evidence map›Paper›PMID 28526731›Full record

ArticleG3 (Bethesda, Md.)2017

Validated Bayesian Differentiation of Causative and Passenger Mutations.

Frederick R Cross, Michal Breker, Kristi Lieberman

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Frederick R CrossThe Rockefeller University, New York, 10065 fcross@mail.rockefeller.edu.
Michal BrekerThe Rockefeller University, New York, 10065.
Kristi LiebermanThe Rockefeller University, New York, 10065.
Rockefeller University · US

Funding

Sources and Consequences of noise in cell cycle regulationR01GM078153 · NIGMS · ROCKEFELLER UNIVERSITY · PI CROSS, FREDERICK R. · 2006 to 2019
$3.3M
NIGMS NIH HHS R01 GM078153
6 · The paper itself

Abstract

In many contexts, the problem arises of determining which of many candidate mutations is the most likely to be causative for some phenotype. It is desirable to have a way to evaluate this probability that relies as little as possible on previous knowledge, to avoid bias against discovering new genes or functions. We have isolated mutants with blocked cell cycle progression in

Indexed as

Genome, PlantMeiosisModels, GeneticMutationArabidopsisBayes TheoremChlamydomonascausative mutationsgenetic screenpassenger mutations

Identifiers

PMID28526731
PMCPMC5499118
OpenAlexW2952557560

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.