Evidence map›Paper›PMID 28526691›Full record

ArticleThe Journal of biological chemistry2017

Zinc deficiency: An unexpected trigger for autophagy.

Binbin Ding, Qing Zhong

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Coordination chemistry suggests that independently observed benefits of metformin and ZnBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Article
  2. Review
  3. Regulation of zinc-dependent enzymes by metal carrier proteins.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Review
  4. Review
  5. Article
  6. Simultaneous ZnNature communications · 2021
    Article
  7. Review
  8. Review
  9. Zinc and Autophagy in Age-Related Macular Degeneration.International journal of molecular sciences · 2020
    Review
  10. Biguanide is a modifiable pharmacophore for recruitment of endogenous ZnBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2019
    Review
  11. Review
  12. Zinc: A Necessary Ion for Mammalian Sperm Fertilization Competency.International journal of molecular sciences · 2018
    Review
  13. Two zinc-binding domains in the transporter AdcA fromThe Journal of biological chemistry · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Binbin DingCenter for Autophagy Research, Department of Internal Medicine, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Qing ZhongCenter for Autophagy Research, Department of Internal Medicine, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390. Electronic address: qing.zhong@utsouthwestern.edu.

Funding

Biochemical Dissection and Reconstitution of Autophagic Membrane FusionR01GM116908 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI ZHONG, QING · 2015 to 2018
$1.3M
NIGMS NIH HHS R01 GM116908
6 · The paper itself

Abstract

Cells respond to deprivation of certain nutrients such as glucose or nitrogen by inducing autophagy, reclaiming pieces of proteins for use in critical functions. A recent study shows that, in yeast, zinc depletion acts in a similar fashion. Depletion of this essential nutrient induces non-selective autophagy by inhibiting TORC1, leading to release and recycling of zinc from degraded proteins.

Indexed as

AutophagyMechanistic Target of Rapamycin Complex 1Multiprotein ComplexesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTOR Serine-Threonine KinasesZincMechanistic Target of Rapamycin Complex 1Multiprotein ComplexesSaccharomyces cerevisiae ProteinsTOR Serine-Threonine KinasesZinc

Identifiers

PMID28526691
PMCPMC5437256

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.