Evidence map›Paper›PMID 28526680›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

Decrease in Numbers of Naive and Resting B Cells in HIV-Infected Kenyan Adults Leads to a Proportional Increase in Total and

Anne E Frosch, Oludare A Odumade, Justin J Taylor, Kathleen Ireland, George Ayodo, Bartholomew Ondigo, David L Narum, John Vulule, Chandy C John

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. HIV-1 Infection Is Associated With Increased Prevalence and Abundance ofFrontiers in cellular and infection microbiology · 2020
    Article
  6. Article
  7. Memory CD4European journal of immunology · 2019
    Article
  8. Development of B Cell Memory in Malaria.Frontiers in immunology · 2019
    Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Anne E FroschDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455; park0587@umn.edu.
Oludare A OdumadeDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455.
Justin J TaylorDepartment of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455.ORCID 0000-0001-9718-2901
Kathleen IrelandDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455.
George AyodoKenyan Medical Research Institute, Kisumu, Kenya.ORCID 0000-0002-5565-2415
Bartholomew OndigoKenyan Medical Research Institute, Kisumu, Kenya.
David L NarumLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852; and.
John VululeKenyan Medical Research Institute, Kisumu, Kenya.ORCID 0000-0001-7710-0390
Chandy C JohnDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455.
University of Minnesota · USKenya Medical Research Institute · KEEgerton University · KEFred Hutch Cancer Center · USNational Institutes of Health · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Infectious Disease Training in Clinical InvestigationT32AI055433 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI David R Boulware · 2003 to 2026
$6.1M
The Effect of HIV Infection on Malaria Specific T and B Cell ResponsesF32AI109808 · NIAID · UNIVERSITY OF MINNESOTA · PI FROSCH, ANNE ELIZABETH PARKER · 2014 to 2014
$58k
NCATS NIH HHS UL1 TR000114NIAID NIH HHS F32 AI109808NIAID NIH HHS T32 AI055433
6 · The paper itself

Abstract

Human immunodeficiency virus type 1 (HIV-1) infection is associated with B cell activation and exhaustion, and hypergammaglobulinemia. How these changes influence B cell responses to coinfections such as malaria is poorly understood. To address this, we compared B cell phenotypes and Abs specific for the

Indexed as

Immunologic MemoryAdolescentAdultAnimalsAntibodies, ProtozoanAntigens, ProtozoanB-Lymphocyte SubsetsCross-Sectional StudiesFemaleFlow CytometryHIV InfectionsHumansImmunophenotypingKenyaLymphocyte ActivationMalaria, FalciparumAntibodies, ProtozoanAntigens, Protozoanapical membrane antigen I, PlasmodiumMembrane ProteinsProtozoan Proteins

Identifiers

PMID28526680
PMCPMC5458331
OpenAlexW2614666655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.