ArticleRegulatory toxicology and pharmacology : RTP2017
Framework for assessing causality of air pollution-related health effects for reviews of the National Ambient Air Quality Standards.
Article in Regulatory toxicology and pharmacology : RTP, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Evidence Synthesis of Observational Studies in Environmental Health: Lessons Learned from a Systematic Review on Traffic-Related Air Pollution.Environmental health perspectives · 2023Pooled it
- Systematic Review and Weight of Evidence Are Integral to Ecological and Human Health Assessments: They Need an Integrated Framework.Integrated environmental assessment and management · 2020Pooled it
- The Effects of Fine Dust, Ozone, and Nitrogen Dioxide on Health.Deutsches Arzteblatt international · 2019Pooled it
- A systematic review of cardiovascular responses associated with ambient black carbon and fine particulate matter.Environment international · 2019Pooled it
- Children's environmental health, environmental justice and PM2.5 regulation in the US, 1997-2024.Environmental health : a global access science source · 2025Article
- Methods for Estimating the Exposure-Response Curve to Inform the New Safety Standards for Fine Particulate Matter.Journal of the Royal Statistical Society. Series A, (Statistics in Society) · 2025Article
- Comparing traditional and causal inference methodologies for evaluating impacts of long-term air pollution exposure on hospitalization with Alzheimer disease and related dementias.American journal of epidemiology · 2025Article
- The last decade of air pollution epidemiology and the challenges of quantitative risk assessment.Environmental health : a global access science source · 2024Review
- Air quality and mental illness: role of bioaerosols, causal mechanisms and research priorities.BJPsych open · 2024Review
- Reviewing umbrella reviews of systematic reviews of original studies on the effects of air pollution on disease.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Advancing the science of a read-across framework for evaluation of data-poor chemicals incorporating systematic and new approach methods.Regulatory toxicology and pharmacology : RTP · 2023Article
- Emulating causal dose-response relations between air pollutants and mortality in the Medicare population.Environmental health : a global access science source · 2021Article
- Assessing additive effects of air pollutants on mortality rate in Massachusetts.Environmental health : a global access science source · 2021Article
- Causal Effects of Air Pollution on Mortality Rate in Massachusetts.American journal of epidemiology · 2020Article
- New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing.International journal of environmental research and public health · 2020Review
- Causal Modeling in Environmental Health.Annual review of public health · 2019Review
- A hierarchical modelling approach to assess multi pollutant effects in time-series studies.PloS one · 2019Article
- Epidemiology: a foundation of environmental decision making.Journal of exposure science & environmental epidemiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
To inform regulatory decisions on the risk due to exposure to ambient air pollution, consistent and transparent communication of the scientific evidence is essential. The United States Environmental Protection Agency (U.S. EPA) develops the Integrated Science Assessment (ISA), which contains evaluations of the policy-relevant science on the effects of criteria air pollutants and conveys critical science judgments to inform decisions on the National Ambient Air Quality Standards. This article discusses the approach and causal framework used in the ISAs to evaluate and integrate various lines of scientific evidence and draw conclusions about the causal nature of air pollution-induced health effects. The framework has been applied to diverse pollutants and cancer and noncancer effects. To demonstrate its flexibility, we provide examples of causality judgments on relationships between health effects and pollutant exposures, drawing from recent ISAs for ozone, lead, carbon monoxide, and oxides of nitrogen. U.S. EPA's causal framework has increased transparency by establishing a structured process for evaluating and integrating various lines of evidence and uniform approach for determining causality. The framework brings consistency and specificity to the conclusions in the ISA, and the flexibility of the framework makes it relevant for evaluations of evidence across media and health effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.