ArticleJournal of vascular surgery2018
A single nucleotide polymorphism of cyclin-dependent kinase inhibitor 1B (p27
Article in Journal of vascular surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Deficiency of p27Journal of vascular research · 2026Article
- Review
- Association of Genetic Variants at theInternational journal of molecular sciences · 2024Article
- Upregulation of miR‑423 improves autologous vein graft restenosis via targeting ADAMTS‑7.International journal of molecular medicine · 2020Article
- Clinical factors that influence the cellular responses of saphenous veins used for arterial bypass.Journal of vascular surgery · 2018Observational
- Mechanotransduction in Coronary Vein Graft Disease.Frontiers in cardiovascular medicine · 2018Article
- Versican is differentially regulated in the adventitial and medial layers of human vein grafts.PloS one · 2018Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundCyclin-dependent kinase inhibitor 1B (p27
methodsHuman saphenous vein adventitial cells and intimal/medial smooth muscle cells (SMCs) were derived from explants obtained at the time of lower extremity bypass operations. We determined the following in adventitial cells and SMCs as a function of the p27 SNP genotype: (1) p27 promoter activity, (2) p27 messenger (m)RNA and protein levels, and (3) growth and collagen gel contraction. Deoxyribonuclease I footprinting was also performed in adventitial cells and SMCs.
resultsp27 promoter activity, deoxyribonuclease I footprinting, p27 mRNA levels, and p27 protein levels demonstrated that the p27 SNP is functional in adventitial cells and SMCs. Both cell types with the graft failure protective AA genotype had more p27 mRNA and protein. As predicted because of higher levels of p27 protein, adventitial cells with the AA genotype grew slower than those of the CC genotype. Unexpectedly, SMCs did not show this genotype-dependent growth response.
conclusionsThese results support the functionality of the p27 SNP in venous SMCs and adventitial cells, but an effect of the SNP on cell proliferation is limited to only adventitial cells. These data point to a potential role for adventitial cells in human vein graft failure and also suggest that SMCs express factors that interfere with the activity of p27.
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Registered trials
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