ArticleAnnals of clinical microbiology and antimicrobials2017
Patients with community-acquired bacteremia of unknown origin: clinical characteristics and usefulness of microbiological results for therapeutic issues: a single-center cohort study.
Article in Annals of clinical microbiology and antimicrobials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04661085 (A Descriptive Study of Patients Suspected With Infection in the Emergency Department, With a Special Focus on Infection With Unknown Origin.), which is not on this map. Cited by 14 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Descriptive Study of Patients Suspected With Infection in the Emergency Department, With a Special Focus on Infection With Unknown Origin.
Who cites it
14 citing papers in PubMed.
- Bloodstream Infections in Non-ICU Hospitalized Patients: Impact of Pathogen Group on Clinical Outcomes-A Retrospective Cohort Study From Türkiye.Infection and drug resistance · 2025Article
- Successful Treatment of Sepsis-Induced Cardiomyopathy with Intra-Aortic Balloon Pumping: A Case Report and Literature Review.The American journal of case reports · 2023Review
- Article
- Clinical and microbiological characteristics of polymicrobial bacteremia: a retrospective, multicenter study.Infection · 2022Review
- The role of [18F]FDG-PET/CT in gram-positive and gram-negative bacteraemia: A systematic review.Frontiers in nuclear medicine · 2022Review
- Profiles of multidrug-resistant organisms among patients with bacteremia in intensive care units: an international ID-IRI survey.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Independent Risk Factors for Sepsis-Associated Cardiac Arrest in Patients with Septic Shock.International journal of environmental research and public health · 2021Observational
- C-reactive protein predicts complications in community-associated S. aureus bacteraemia: a cohort study.BMC infectious diseases · 2021Article
- Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing.Genome biology · 2021Article
- Molecular Evidence of a Broad Range of Pathogenic Bacteria inTropical medicine and infectious disease · 2021Article
- Risk Factors for the Acquisition ofAntibiotics (Basel, Switzerland) · 2021Article
- Antimicrobial resistance of bacteraemia in the emergency department of a German university hospital (2013-2018): potential carbapenem-sparing empiric treatment options in light of the new EUCAST recommendations.BMC infectious diseases · 2019Article
- Amoxicillin/clavulanic acid+aminoglycoside as empirical antibiotic treatment in severe community-acquired infections with diagnostic uncertainty.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Observational
- Bacteraemia in emergency departments: effective antibiotic reassessment is associated with a better outcome.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteremia of unknown origin (BUO) are associated with increased mortality compared to those with identified sources. Microbiological data of those patients could help to characterize an appropriate empirical antibiotic treatment before bloodcultures results are available during sepsis of unknown origin. Based on the dashboard of our ward that prospectively records several parameters from each hospitalization, we report 101 community-acquired BUO selected among 1989 bacteremic patients from July 2005 to April 2016, BUO being defined by the absence of clinical and paraclinical infectious focus and no other microbiological samples retrieving the bacteria isolated from blood cultures. The in-hospital mortality rate was 9%. We retrospectively tested two antibiotic associations: amoxicillin-clavulanic acid + gentamicin (AMC/GM) and 3rd generation cephalosporin + gentamicin (3GC/GM) considered as active if the causative bacteria was susceptible to at least one of the two drugs. The mean age was 71 years with 67% of male, 31 (31%) were immunocompromised and 52 (51%) had severe sepsis. Eleven patients had polymicrobial infections. The leading bacterial species involved were Escherichia coli 25/115 (22%), group D Streptococci 12/115 (10%), viridans Streptococci 12/115 (10%) and Staphylococcus aureus 11/115 (9%). AMC/GM displayed a higher rate of effectiveness compared to 3GC/GM: 100/101 (99%) vs 94/101 (93%) (p = 0.04): one Enterococcus faecium strain impaired the first association, Bacteroides spp. and Enterococcus spp. the second. In case of community-acquired sepsis of unknown origin, AMC + GM should be considered.
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