ArticleBMC surgery2017
Rectal-sparing type of ulcerative colitis predicts lack of response to pharmacotherapies.
Article in BMC surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Diagnosis and Monitoring of Ulcerative Colitis.Clinics in colon and rectal surgery · 2022Review
- Association of young age and male sex with primary sclerosing cholangitis in Taiwanese patients with inflammatory bowel disease.Intestinal research · 2022Article
- Stepwise Treatment With Plant-Based Diet and Medication for Patient With Mild Ulcerative Colitis.The Permanente journal · 2021Article
- Clinical characteristics and prognosis of patients with ulcerative colitis that shows rectal sparing at initial diagnosis.World journal of gastrointestinal endoscopy · 2021Article
- Reduced CD27Frontiers in immunology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUlcerative colitis (UC) is known as an immune disorder of the colon that generally involves the rectum, but an atypical distribution of inflamed mucosa has previously been noted in certain subtypes of UC, such as the rectal-sparing type (RST). As noted in a previous report, patients with the RST may be at elevated risk for disease refractoriness, but the clinical significance of RST remains unknown.
methodsUC patients who underwent surgery between January 2010 and April 2015 were included. Patients were classified as having the RST or a non-RST based on colectomy specimens or a pre-operative endoscopy. Possible risk factors for urgent/emergent surgery were analyzed. We specifically determined whether the RST is a significant predictor for urgent/emergent surgery.
resultsIn total, 46/482 patients were classified as having the RST. Disease severity was significantly worse in patients with the RST than in other patients (p = 0.02). Urgent/emergent surgery was required for 24/46 patients with the RST, compared with 107/436 non-RST patients (p < 0.01). The overall incidence of urgent/emergent surgery was 131/482. Disease duration < 70.2 months [odds ratio (OR) 2.45], severe disease (OR 87.1), total administered steroid dose < 5000 mg (OR 3.02), daily pre-operative steroid dose ≥ 9 mg (OR 2.59), and the RST (OR 5.59) were identified as independent risk factors for urgent/emergent surgery.
conclusionThe RST was an independent risk factor for urgent/emergent surgery in our analysis of surgically treated patients with UC.
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