Trial reportBMC neurology2017
The intracerebral hemorrhage acutely decreasing arterial pressure trial II (ICH ADAPT II) protocol.
Trial report in BMC neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02281838 (The Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial II), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial II
Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Lower Blood Pressure Is Not Associated With Decreased Arterial Spin Labeling Estimates of Perfusion in Intracerebral Hemorrhage.Journal of the American Heart Association · 2019Trial
- U shaped relationship between mean arterial pressure and 28 day mortality in ICU patients with acute myocardial infarction.Scientific reports · 2025Article
- Premorbid Blood Pressure Control Modifies Risk of DWI Lesions With Acute Blood Pressure Reduction in Intracerebral Hemorrhage.Hypertension (Dallas, Tex. : 1979) · 2024Observational
- Changes in Cerebral Blood Flow and Diffusion-Weighted Imaging Lesions After Intracerebral Hemorrhage.Translational stroke research · 2022Review
- Remote diffusion-weighted imaging lesions and blood pressure variability in primary intracerebral hemorrhage.Frontiers in neurology · 2022Article
- Acute Blood Pressure Management in Acute Ischemic Stroke and Spontaneous Cerebral Hemorrhage.Current treatment options in neurology · 2018Review
- Therapeutic Approach to Hypertensive Emergencies: Hemorrhagic Stroke.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2018Review
- Injury mechanisms in acute intracerebral hemorrhage.Neuropharmacology · 2018Review
- Blood Pressure Goals in Acute Stroke-How Low Do You Go?Current hypertension reports · 2018Review
- Secondary Hematoma Expansion and Perihemorrhagic Edema after Intracerebral Hemorrhage: From Bench Work to Practical Aspects.Frontiers in neurology · 2017Review
- Remote Diffusion-Weighted Imaging Lesions in Intracerebral Hemorrhage: Characteristics, Mechanisms, Outcomes, and Therapeutic Implications.Frontiers in neurology · 2017Review
- Evolution of blood pressure management in acute intracerebral hemorrhage.F1000Research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAggressively lowering blood pressure (BP) in acute intracerebral hemorrhage (ICH) may improve outcome. Although there is no evidence that BP reduction changes cerebral blood flow, retrospective magnetic resonance imaging (MRI) studies have demonstrated sub-acute ischemic lesions in ICH patients. The primary aim of this study is to assess ischemic lesion development in patients randomized to two different BP treatment strategies. We hypothesize aggressive BP reduction is not associated with ischemic injury after ICH.
methodsThe Intracerebral Hemorrhage Acutely Decreasing Blood Pressure Trial II (ICH ADAPT II) is a phase II multi-centre randomized open-label, blinded-endpoint trial. Acute ICH patients (N = 270) are randomized to a systolic blood pressure (SBP) target of <140 or <180 mmHg. Acute ICH patients within 6 h of onset and two SBP measurements ≥140 mmHg recorded >2 mins apart qualify. SBP is managed with a pre-defined treatment protocol. Patients undergo MRI at 48 h, Days 7 and 30, with clinical assessment at Day 30 and 90. The primary outcome is diffusion weighted imaging (DWI) lesion frequency at 48 h. Secondary outcomes include cumulative DWI lesion rate frequency within 30 days, absolute hematoma growth, prediction of DWI lesion incidence, 30-day mortality rates, day 90 functional outcome, and cognitive status. DISCUSSION: This trial will assess the impact of hypertensive therapies on physiological markers of ischemic injury. The findings of this study will provide evidence for the link, or lack thereof, between BP reduction and ischemic injury in ICH patients.
trial registrationThis study is registered with clinicaltrials.gov ( NCT02281838 , first received October 29, 2014).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.