ArticleBMC neurology2017
Association of fibrinogen level with early neurological deterioration among acute ischemic stroke patients with diabetes.
Article in BMC neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- Association of Blood Pressure with Neurological Function Decline and Functional Outcome in Patients of Watershed Infarction.Neuropsychiatric disease and treatment · 2025Trial
- The efficacy and safety of endovascular treatment for acute ischemic progressive stroke beyond 24 h.BMC neurology · 2026Article
- Stage-dependent alterations of Sonoclot coagulation profiles across the spectrum of diabetic peripheral neuropathy.Frontiers in endocrinology · 2026Article
- Detailed Analysis of Thrombus Composition and Endovascular Thrombectomy Efficiency in Ischemic Stroke Patients with Middle Cerebral Artery Occlusion Undergoing Thrombectomy.Journal of clinical medicine · 2025Article
- Nomogram for predicting the occurrence of progressive ischemic stroke: a single-center retrospective study.European journal of medical research · 2025Article
- Predictive Model for Early Neurological Deterioration in Acute Ischemic Stroke Utilizing Novel Thrombotic Biomarkers.Brain and behavior · 2025Article
- Emerging biomarkers in ischemic stroke.Vessel plus · 2025Article
- Plasma fibrinogen as a potential biomarker of cognitive impairment after acute ischemic stroke.Scientific reports · 2024Article
- Whether coagulation dysfunction influences the onset and progression of diabetic peripheral neuropathy: A multicenter study in middle-aged and aged patients with type 2 diabetes.CNS neuroscience & therapeutics · 2024Article
- Behavior of Extracranial-to-Intracranial Extended Arterial Dissections of the Vertebral Artery.Journal of the American Heart Association · 2024Article
- Glycated serum protein is independently associated with progressive infarction in patients with acute ischemic stroke.The Journal of international medical research · 2024Article
- Comparison of outcomes between anticoagulation and antiplatelet therapies for intracranial arterial dissections.Frontiers in neurology · 2024Article
- Significance of headache in intracranial vertebrobasilar artery dissections: an observational study.Scientific reports · 2023Observational
- Neutrophil-to-Lymphocyte Ratio as a Predictor of Short-Term Functional Outcomes in Acute Ischemic Stroke Patients.International journal of environmental research and public health · 2023Article
- Fibrinogen as a Predictor of Early Neurological Deterioration in Acute Ischemic Stroke - Evidence From the Indian Population.Journal of central nervous system disease · 2023Article
- Higher Plasma Fibrinogen Level at Admission Is Associated with Post-Stroke Depression at Discharge.Brain sciences · 2022Article
- Lymphocyte-to-Monocyte Ratio Is Independently Associated with Progressive Infarction in Patients with Acute Ischemic Stroke.BioMed research international · 2022Article
- Influence of endothelial function and arterial stiffness on the behavior of cervicocephalic arterial dissections: An observational study.Frontiers in neurology · 2022Article
- Clinical and Non-Clinical Determinants of the Effect of Mechanical Thrombectomy and Post-Stroke Functional Status of Patients in Short and Long-Term Follow-Up.Journal of clinical medicine · 2021Article
- Diabetes, Vascular Aging and Stroke: Old Dogs, New Tricks?Journal of clinical medicine · 2021Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes mellitus (DM) is a risk factor for early neurological deterioration (END) in acute ischemic stroke. The prothrombotic protein fibrinogen is frequently elevated in patients with diabetes, and may be associated with poorer prognoses. We evaluated whether fibrinogen is associated with END in patients with diabetes after acute ischemic stroke.
methodsWe included 3814 patients from a single hospital database admitted within 72 h of onset of ischemic stroke. END was defined as an increase in the National Institutes of Health Stroke Scale (NIHSS) ≥2 within 7 days post-admission. In the total population (END, n = 661; non-END, n = 3153), univariate and multivariate analyses were performed to assess fibrinogen as an independent predictor for END. We then performed propensity score matching and univariate analyses for DM (END, n = 261; non-END, n = 522) and non-DM populations (END, n = 399; non-END, n = 798). Multiple logistic analyses were performed after matching for fibrinogen as a risk factor in each subgroup.
resultsFibrinogen levels were higher in the END group than in the non-END group (367 ± 156 mg/dL vs. 347 ± 122 mg/dL, p = 0.002), though they were not associated with END in logistic regression analyses. Fibrinogen levels were found to be an independent predictor for END, but only in the DM population (fibrinogen levels 300-599 mg/dL, odds ratio: 1.618, 95% confidence interval: 1.037-2.525, p = 0.034, fibrinogen levels ≥600 mg/dL, 2.575, 1.018-6.514, p = 0.046; non-DM population, p = 0.393). The diabetes-fibrinogen interaction for the entire cohort was p = 0.101.
conclusionsElevated fibrinogen is dose-dependently associated with END in patients with diabetes following acute ischemic stroke.
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