ArticleDrug and alcohol dependence2017
Peripheral immune factors are elevated in women with current or recent alcohol dependence and associated with altered mood and memory.
Article in Drug and alcohol dependence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Effect of alcohol on Brain-Derived Neurotrophic Factor (BDNF) blood levels: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- The Interplay of Inflammatory Processes and Cognition in Alcohol Use Disorders-A Systematic Review.Frontiers in psychiatry · 2019Pooled it
- Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders.Life (Basel, Switzerland) · 2024Review
- Imaging the brain's immune response to alcohol with [Molecular psychiatry · 2023Article
- Review
- A review on the reciprocal interactions between neuroinflammatory processes and substance use and misuse, with a focus on alcohol misuse.The American journal of drug and alcohol abuse · 2023Review
- Sex differences in cardiopulmonary effects of acute bromine exposure.Toxicology research · 2021Article
- Toward a better understanding of inflammatory microvesicles in alcohol use disorder.Journal of neuroscience research · 2021Review
- The Interaction of Inflammatory Markers and Alcohol-Use on Cognitive Function in Korean Male Firefighters.Psychiatry investigation · 2021Article
- Brain-derived neurotrophic factor (BDNF) is associated with depressive symptoms in older adults with HIV disease.Journal of neurovirology · 2021Article
- Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Protracted Alcohol Withdrawal Symptoms in Male Alcohol-Dependent Patients.Frontiers in psychiatry · 2021Article
- Neuroinflammation in psychiatric disorders: An introductory primer.Pharmacology, biochemistry, and behavior · 2020Article
- Neuroinflammation in addiction: A review of neuroimaging studies and potential immunotherapies.Pharmacology, biochemistry, and behavior · 2019Review
- S100B and Inflammatory Cytokine Levels in Blood as Potential Markers of Blood-Brain Barrier Damage and Psychiatric Impairment in Comorbid Hepatitis C Viral Infection and Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2018Article
- The relationship between interleukin-6 and functional connectivity in methamphetamine users.Neuroscience letters · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe adverse effects of alcohol on brain function result, in part, from inflammatory processes. The sex-specific neuropsychiatric consequences and inflammatory status of active alcohol dependence and early remission from dependence have not been investigated.
methodsNeuropsychiatric symptoms, inflammatory factors, and liver enzymes were compared in a prospective cohort study of adults with (n=51) or without (n=31) a current or recent history of alcohol dependence.
resultsNeuropsychiatric profiles were similar in adults with current or recent alcohol dependence regardless of sex. In male and female participants measures of depression (female p<0.05, male p<0.001), anxiety (female p<0.001, male p<0.001), and memory complaints (female p<0.001, male p<0.05) were elevated, relative to non-dependent controls. Significant sex×alcohol dependence history interactions were observed for plasma levels of tissue inhibitor of metalloproteinase 1 (TIMP-1) and brain derived neurotrophic factor (BDNF), with women in the alcohol dependent group exhibiting increased levels of both analytes (p<0.05) relative to controls. Positive correlations between TIMP-1 levels and measures of depression (r
conclusionsThough neuropsychiatric profiles were similar for men and women with current or recent alcohol dependence, plasma factors associated with increases in depression, anxiety, and memory impairment differed and support the need to tailor treatments based on sex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.