Evidence map›Paper›PMID 28525625›Full record

ArticleAmerican journal of epidemiology2017

Characteristics of US-Born Versus Foreign-Born Americans of African Descent With Chronic Hepatitis B.

Mohamed A Hassan, W Ray Kim, Ruosha Li, Coleman I Smith, Michael W Fried, Richard K Sterling, Marc G Ghany, Abdus S Wahed, Lilia M Ganova-Raeva, Lewis R Roberts and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 1 country.

Mohamed A Hassan
W Ray Kim
Ruosha Li
Coleman I Smith
Michael W Fried
Richard K Sterling
Marc G Ghany
Abdus S Wahed
Lilia M Ganova-Raeva
Lewis R Roberts
Anna S F Lok
Hepatitis B Research Network
Georgetown University · USMayo Clinic in Arizona · USNational Institutes of Health · USStanford University · USThe University of Texas Health Science Center at Houston · USUniversity of Michigan–Ann Arbor · USUniversity of Minnesota System · USUniversity of Pittsburgh · USVirginia Commonwealth University · US

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
MICHIGAN INSTITUTE FOR CLINICAL AND HEALTH RESEARCH (MICHR) (UL1): (BPCA)UL1RR024986 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHANLEY, THOMAS P. · 2007 to 2011
$51.2M
North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
Hepatitis B Research Network - Data Coordination CenterU01DK082864 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BELLE, STEVEN H. · 2008 to 2019
$25.3M
Center for Clinical and Translational ResearchUL1TR000058 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2012 to 2015
$12.5M
Natural History, Therapy and Pathogenesis of Chronic Viral Hepatitis BZIADK054517 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GHANY, MARC · 2009 to 2025
$9.6M
Hepatitis B Clinical Research Network Clinical Center: Michigan - Hawaii ConsortiumU01DK082863 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOK, ANNA S.F. · 2008 to 2020
$3.7M
The North Carolina Hepatitis Beta Clinical Research NetworkU01DK082867 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRIED, MICHAEL W · 2008 to 2019
$3.4M
Hepatitis B Clinical Research NetworkU01DK082923 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI STERLING, RICHARD K. · 2008 to 2019
$3.2M
Optimal Long-term Outcome of Chronic Hepatitis BU01DK082843 · NIDDK · MAYO CLINIC ROCHESTER · PI ROBERTS, LEWIS R · 2008 to 2014
$2.0M
Patient-oriented and effectiveness research in chronic liver diseaseK24DK092336 · NIDDK · STANFORD UNIVERSITY · PI KIM, W. RAY · 2012 to 2016
$627k
NCATS NIH HHS UL1 TR000058NCATS NIH HHS UL1 TR001111NCATS NIH HHS UL1 TR002240NCRR NIH HHS UL1 RR024986NIDDK NIH HHS K24 DK092336NIDDK NIH HHS U01 DK082843NIDDK NIH HHS U01 DK082863NIDDK NIH HHS U01 DK082864NIDDK NIH HHS U01 DK082867NIDDK NIH HHS U01 DK082923
6 · The paper itself

Abstract

Hepatitis B virus (HBV) infection is more common in African Americans than in white Americans. We compared the epidemiologic, clinical, and virological characteristics of US-born African Americans (USAAs) to those of foreign-born African Americans (FBAAs) with chronic hepatitis B. The adult cohort study of the Hepatitis B Research Network enrolls patients with HBV infection from 21 clinical sites in the United States and Canada. A total of 237 (15%) of the adult participants with chronic HBV infection that were enrolled from January 20, 2011, to October 2, 2013, were of African descent, including 57 USAAs and 180 FBAAs (76%). Compared with FBAAs, USAAs were older and more likely to have acquired HBV through sexual exposure, to be HBeAg-positive, to have higher HBV DNA levels, and to be infected with HBV genotype A2. FBAAs from West Africa were more likely to have elevated serum alanine aminotransferase (72% vs. 50%; P < 0.01) and higher HBV DNA levels (median, 3.2 log10 IU/mL vs. 2.8 log10 IU/mL; P = 0.03) compared with East African FBAAs. The predominant HBV genotype among West African FBAAs was E (67%), whereas genotypes A (78%) and D (16%) were common in East African FBAAs. Significant differences were found between USAAs and FBAAs, highlighting the need for tailored strategies for prevention and management of chronic HBV infection for African Americans.

Indexed as

AdultAfrica, EasternAfrica, WesternBlack or African AmericanCanadaFemaleHepatitis B, ChronicHumansMaleMiddle AgedRisk FactorsUnited StatesAfrican Americangenotypehepatitis B e antigenhepatitis B virusmode of transmission

Identifiers

PMID28525625
PMCPMC5860424
OpenAlexW2615243855

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.