ArticleToxicological sciences : an official journal of the Society of Toxicology2017
From the Cover: Aloin, a Component of the Aloe Vera Plant Leaf, Induces Pathological Changes and Modulates the Composition of Microbiota in the Large Intestines of F344/N Male Rats.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Cardioprotective Effects ofLife (Basel, Switzerland) · 2026Review
- Aloe polysaccharide promotes keratinocyte proliferation, migration, and differentiation by upregulating the EGFR/PKC-dependent signaling pathways.Scientific reports · 2025Article
- Aloin protects against UVB-induced apoptosis by modulating integrated signaling pathways.Frontiers in pharmacology · 2025Article
- Shouhui Tongbian Capsule ameliorates 5-fluorouracil induced constipation in mice by modulating gut microbiota and activating PI3K/AKT/AQP3 signaling pathway.Frontiers in microbiology · 2025Article
- L. acidophilus/L. johnsonii ratio affects slow transit constipation in rats.Scientific reports · 2024Article
- Review
- Application of the herbal chemical marker ranking system (Herb MaRS) to the standardization of herbal raw materials: a case study.BMC complementary medicine and therapies · 2023Article
- Microbiota-derived short chain fatty acids in fermented Kidachi Aloe promote antimicrobial, anticancer, and immunomodulatory activities.BMC microbiology · 2023Article
- The dark side of miracle plant-Aloe vera: a review.Molecular biology reports · 2022Review
- Temperature and pH Stability of Anthraquinones from NativeFoods (Basel, Switzerland) · 2022Article
- Aloin induced apoptosis by enhancing autophagic flux through the PI3K/AKT axis in osteosarcoma.Chinese medicine · 2021Article
- The toxicologic pathology aspects of selected natural herbal products and related compounds.Journal of toxicologic pathology · 2021Review
- Review on the phytochemistry and toxicological profiles ofFuture journal of pharmaceutical sciences · 2021Review
- Absence of genotoxicity of purifiedToxicology reports · 2021Article
- Network Pharmacology-Based Study on the Mechanism of Aloe Vera for Treating Cancer.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Evaluation of anti-infective potencies of formulated aloin A ointment and aloin A isolated fromBMC chemistry · 2020Article
- Modulation of gut microbiota in healthy rats after exposure to nutritional supplements.Gut microbes · 2020Review
- Pharmacological Update Properties ofMolecules (Basel, Switzerland) · 2020Review
- Undervalued potential of crassulacean acid metabolism for current and future agricultural production.Journal of experimental botany · 2019Review
- Finding the bad actor: Challenges in identifying toxic constituents in botanical dietary supplements.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a previous study, the oral administration of an Aloe vera whole leaf extract induced dose-related mucosal and goblet cell hyperplasia in the rat colon after 13 weeks and colon cancer after 2 years. The primary goal of this study was to determine whether or not the administration of aloin, a component of the Aloe vera plant leaf, would replicate the pathophysiological effects that were observed in rats in the previous study with an Aloe vera whole leaf extract. Groups of 10 male F344/N rats were administered aloin at 0, 6.95, 13.9, 27.8, 55.7, 111, 223, and 446 mg/kg drinking water for 13 weeks. At the end of study, rat feces were collected, and the composition of fecal bacteria was investigated by next generation sequencing of the PCR-amplified V3/V4 region of the 16S rRNA gene. At necropsy, blood was collected by cardiac puncture and organs and sections of the large intestine were collected for histopathology. Aloin induced dose-related increased incidences and severities of mucosal and goblet cell hyperplasia that extended from the cecum to the rectum, with increased incidences and severities detected at aloin doses ≥55.7 mg/kg drinking water. Analysis of the 16S rRNA metagenomics sequencing data revealed marked shifts in the structure of the gut microbiota in aloin-treated rats at each taxonomic rank. This study highlights the similarities in effects observed for aloin and the Aloe vera whole leaf extract, and points to a potential mechanism of action to explain the observed pathological changes via modulation of the gut microbiota composition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.