ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Influenza Vaccination Modifies Disease Severity Among Community-dwelling Adults Hospitalized With Influenza.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.
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Who cites it
89 citing papers in PubMed, 1 synthesis or guideline pooled it, 182 citations in OpenAlex.
- The Cost of Seasonal Influenza: A Systematic Literature Review on the Humanistic and Economic Burden of Influenza in Older (≥ 65 Years Old) Adults.Advances in therapy · 2024Pooled it
- A Retrospective Test-Negative Case-Control Study to Evaluate Influenza Vaccine Effectiveness in Preventing Hospitalizations in Children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Trial
- Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19.The New England journal of medicine · 2021Trial
- Influenza vaccine effectiveness and disease burden in children and adolescents with sickle cell disease: 2012-2017.Pediatric blood & cancer · 2020Trial
- Effect of seasonal influenza vaccination on influenza symptom severity among children in Hutterite communities: Follow-up study of a randomized trial.Influenza and other respiratory viruses · 2020Trial
- Article
- Influenza Vaccine and Associated Infection and Death in California, 2024 to 2025.JAMA network open · 2026Article
- Article
- Severity of Clinical Presentation and Outcomes in Hospitalized Adult People With Influenza by Type and Subtype, United States-2017-2020.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Article
- Review
- Effect of Influenza Vaccination on the Disease Severity and Viral Load Among Adult Outpatients and Inpatients.Vaccines · 2025Article
- Comparative Analysis of Severe Clinical Outcomes in Hospitalized Patients with RSV, Influenza, and COVID-19 Across Early and Late COVID-19 Pandemic Phases (2021-2024).Journal of clinical medicine · 2025Article
- The potential global health impact and cost-effectiveness of next-generation influenza vaccines: A modelling analysis.PLoS medicine · 2025Article
- Identification and characterisation of clinically distinct subgroups of adults hospitalised with influenza in the USA: a repeated cross-sectional study.EClinicalMedicine · 2025Article
- Acute Influenza Virus-Associated Encephalitis and Other Neurological Complications in Severe Hospitalized Laboratory-Confirmed Influenza Cases-Catalonia 2010-2020.Pathogens (Basel, Switzerland) · 2025Article
- Effectiveness of 2023 southern hemisphere influenza vaccines against severe influenza-associated illness: pooled estimates from eight countries using the test-negative design.The Lancet. Global health · 2025Article
- Knowledge, attitudes, barriers and uptake rate of influenza virus vaccine among adults with chronic diseases in Jordan: a multicentric cross-sectional study.Frontiers in public health · 2025Article
- Disentangling behavioral determinants of seasonal influenza vaccination in post-corona era: An integrated model approach.PloS one · 2025Article
- Estimated Effectiveness of Influenza Vaccines in Preventing Secondary Infections in Households.JAMA network open · 2024Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 14 institutions in 2 countries.
Funding
Abstract
Background: We investigated the effect of influenza vaccination on disease severity in adults hospitalized with laboratory-confirmed influenza during 2013-14, a season in which vaccine viruses were antigenically similar to those circulating. Methods: We analyzed data from the 2013-14 influenza season and used propensity score matching to account for the probability of vaccination within age strata (18-49, 50-64, and ≥65 years). Death, intensive care unit (ICU) admission, and hospital and ICU lengths of stay (LOS) were outcome measures for severity. Multivariable logistic regression and competing risk models were used to compare disease severity between vaccinated and unvaccinated patients, adjusting for timing of antiviral treatment and time from illness onset to hospitalization. Results: Influenza vaccination was associated with a reduction in the odds of in-hospital death among patients aged 18-49 years (adjusted odds ratios [aOR] = 0.21; 95% confidence interval [CI], 0.05 to 0.97), 50-64 years (aOR = 0.48; 95% CI, 0.24 to 0.97), and ≥65 years (aOR = 0.39; 95% CI, 0.17 to 0.66). Vaccination also reduced ICU admission among patients aged 18-49 years (aOR = 0.63; 95% CI, 0.42 to 0.93) and ≥65 years (aOR = 0.63; 95% CI, 0.48 to 0.81), and shortened ICU LOS among those 50-64 years (adjusted relative hazards [aRH] = 1.36; 95% CI, 1.06 to 1.74) and ≥65 years (aRH = 1.34; 95% CI, 1.06 to 1.73), and hospital LOS among 50-64 years (aRH = 1.13; 95% CI, 1.02 to 1.26) and ≥65 years (aRH = 1.24; 95% CI, 1.13 to 1.37). Conclusions: Influenza vaccination during 2013-14 influenza season attenuated adverse outcome among adults that were hospitalized with laboratory-confirmed influenza.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.