ArticleNucleic acids research2017
Crosstalk between vertical and horizontal gene transfer: plasmid replication control by a conjugative relaxase.
Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Performance of the pBHR1 mobilization protein MobV and its role in stable plasmid expression inMicrobiology spectrum · 2026Article
- Horizontal and vertical gene transfer shape the plasmid host range in surface-associated microbial systems.iScience · 2026Article
- Unveiling the Mechanisms of Bacterial Resistance and Countermeasures.Pathogens (Basel, Switzerland) · 2025Review
- Plasmid Genomic Dynamics and One Health: Drivers of Antibiotic Resistance and Pathogenicity.Pathogens (Basel, Switzerland) · 2025Review
- Beyond the Blood Cell: The Emerging Role of Cell-Free DNA in Transfusion Medicine.Journal of hematology · 2025Review
- Article
- Dispersion of antimicrobial resistant bacteria in pig farms and in the surrounding environment.Animal microbiome · 2024Article
- Transcriptional control of two distinct lactococcal plasmid-encoded conjugation systems.Current research in microbial sciences · 2024Article
- Article
- Antibiotic Resistance and Food Safety: Perspectives on New Technologies and Molecules for Microbial Control in the Food Industry.Antibiotics (Basel, Switzerland) · 2023Review
- Application of antimicrobial, potential hazard and mitigation plans.Environmental research · 2022Review
- Interactions of theMicroorganisms · 2021Article
- ComprehensiveMicrobial genomics · 2021Article
- An Overview of the Potential Therapeutic Applications of Essential Oils.Molecules (Basel, Switzerland) · 2021Review
- Conjugative plasmid-encoded toxin-antitoxin system PrpT/PrpA directly controls plasmid copy number.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Recognition of Streptococcal Promoters by the Pneumococcal SigA Protein.Frontiers in molecular biosciences · 2021Article
- Plasmid Characteristics Modulate the Propensity of Gene Exchange in Bacterial Vesicles.Journal of bacteriology · 2019Article
- Reconsidering plasmid maintenance factors for computational plasmid design.Computational and structural biotechnology journal · 2019Review
- Regulation of Gram-Positive Conjugation.Frontiers in microbiology · 2019Review
- Relaxase MobM Induces a Molecular Switch at Its Cognate Origin of Transfer.Frontiers in molecular biosciences · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Horizontal gene transfer is a key process in the evolution of bacteria and also represents a source of genetic variation in eukaryotes. Among elements participating in gene transfer, thousands of small (<10 kb) mobile bacterial plasmids that replicate by the rolling circle mechanism represent a driving force in the spread of antibiotic resistances. In general, these plasmids are built as genetic modules that encode a replicase, an antibiotic-resistance determinant, and a relaxase that participates in their conjugative mobilization. Further, they control their relatively high copy number (∼30 copies per genome equivalent) by antisense RNAs alone or combined with a repressor protein. We report here that the MobM conjugative relaxase encoded by the promiscuous plasmid pMV158 participates in regulation of the plasmid copy number by transcriptional repression of the antisense RNA, thus increasing the number of plasmid molecules ready to be horizontally transferred (mobilization) and/or vertically inherited (replication). This type of crosstalk between genetic modules involved in vertical and horizontal gene flow has not been reported before.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.