ArticleJournal of the American Chemical Society2017
Self-Healing, Self-Assembled β-Sheet Peptide-Poly(γ-glutamic acid) Hybrid Hydrogels.
Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Mechanically Enhanced Ultrashort Peptide Hydrogels for pH-Triggered Release.ACS polymers Au · 2026Article
- Semi-Interpenetrated Polymeric Networks of Chitosan and Poly(γ-Glutamic Acid) with Potential Biomedical Applications.ACS omega · 2026Article
- Self-Assembled Hydrogels: A Novel Drug Delivery System for Osteoarthritis.Current issues in molecular biology · 2026Review
- Programming Hydrogel Mechanics via Sequence-Controlled Polymerization Using Peptide Self-Assembly.Journal of the American Chemical Society · 2026Article
- Novel copper-ion coordinated andrographolide-loaded hydrogel activates Rac1/JNK1 axis for enhancing diabetic wound healing.NPJ Regenerative medicine · 2026Article
- Ion Valency as a Molecular Switch for Salt-Resistant Underwater Adhesion.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Mechanoresponsive Hydrogels Emerging from Dynamic and Non-Covalent Interactions.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Integrated transcriptomic and metabolomic analysis reveals stage-associated molecular profiles in Ophiocordyceps sinensis.BMC genomics · 2025Article
- Synthetic Polymers for Drug, Gene, and Vaccine Delivery.Polymer science & technology (Washington, D.C.) · 2025Review
- Non-coding RNAs as therapeutic targets and biomarkers in ischaemic heart disease.Nature reviews. Cardiology · 2024Review
- Biomimetic Non-ergodic Aging by Dynamic-to-covalent Transitions in Physical Hydrogels.ACS applied materials & interfaces · 2024Article
- Biostable hydrogels consisting of hybrid β-sheet fibrils assembled by a pair of enantiomeric peptides.Materials today. Bio · 2024Article
- Emerging Advances in Microfluidic Hydrogel Droplets for Tissue Engineering and STEM Cell Mechanobiology.Gels (Basel, Switzerland) · 2023Review
- Collagen-Binding Peptide-Enabled Supramolecular Hydrogel Design for Improved Organ Adhesion and Sprayable Therapeutic Delivery.Nano letters · 2022Article
- Bispidine as a β-strand nucleator: from a β-arch to self-assembled cages and vesicles.Chemical science · 2021Article
- An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination.Nature communications · 2021Article
- From Residues to Added-Value Bacterial Biopolymers as Nanomaterials for Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2021Review
- (Macro)molecular self-assembly for hydrogel drug delivery.Advanced drug delivery reviews · 2021Review
- Physical networks from entropy-driven non-covalent interactions.Nature communications · 2021Article
- Natural-Based Hydrogels for Tissue Engineering Applications.Molecules (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Self-assembled biomaterials are an important class of materials that can be injected and formed in situ. However, they often are not able to meet the mechanical properties necessary for many biological applications, losing mechanical properties at low strains. We synthesized hybrid hydrogels consisting of a poly(γ-glutamic acid) polymer network physically cross-linked via grafted self-assembling β-sheet peptides to provide non-covalent cross-linking through β-sheet assembly, reinforced with a polymer backbone to improve strain stability. By altering the β-sheet peptide graft density and concentration, we can tailor the mechanical properties of the hydrogels over an order of magnitude range of 10-200 kPa, which is in the region of many soft tissues. Also, due to the ability of the non-covalent β-sheet cross-links to reassemble, the hydrogels can self-heal after being strained to failure, in most cases recovering all of their original storage moduli. Using a combination of spectroscopic techniques, we were able to probe the secondary structure of the materials and verify the presence of β-sheets within the hybrid hydrogels. Since the polymer backbone requires less than a 15% functionalization of its repeating units with β-sheet peptides to form a hydrogel, it can easily be modified further to incorporate specific biological epitopes. This self-healing polymer-β-sheet peptide hybrid hydrogel with tailorable mechanical properties is a promising platform for future tissue-engineering scaffolds and biomedical applications.
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