Evidence map›Paper›PMID 28524857›Full record

ArticleCell death and differentiation2017

A defined metabolic state in pre B cells governs B-cell development and is counterbalanced by Swiprosin-2/EFhd1.

Merle Stein, Sebastian Dütting, Dimitrios Mougiakakos, Michael Bösl, Kristin Fritsch, Dorothea Reimer, Sophia Urbanczyk, Tobit Steinmetz, Wolfgang Schuh, Aline Bozec and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Cell death and differentiation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 74 citations in OpenAlex.

  1. Review
  2. A guide to B cell metabolism.Nature reviews. Immunology · 2026
    Review
  3. Article
  4. Excessive CabioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells.Journal of visualized experiments : JoVE · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Multifaceted roles of mitochondria in asthma.Cell biology and toxicology · 2024
    Review
  15. Lipid metabolism in B cell biology.Molecular oncology · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Merle SteinDepartment of Internal Medicine 3, Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
Sebastian DüttingDepartment of Internal Medicine 3, Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
Dimitrios MougiakakosDepartment of Internal Medicine V, University Clinic, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
Michael BöslDepartment of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of Würzburg, Würzburg D-97080, Germany.
Kristin FritschDepartment of Internal Medicine 3, Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
Dorothea ReimerDepartment of Internal Medicine 3, Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
Sophia UrbanczykDepartment of Internal Medicine 3, Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
Tobit SteinmetzDepartment of Internal Medicine 3, Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
Wolfgang SchuhDepartment of Internal Medicine 3, Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
Aline BozecDepartment of Internal Medicine III, University Clinic, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
Thomas H WinklerDepartment of Biology, Nikolaus-Fiebiger-Center, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
Hans-Martin JäckDepartment of Internal Medicine 3, Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
Dirk MielenzDepartment of Internal Medicine 3, Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

B-cell development in the bone marrow comprises proliferative and resting phases in different niches. We asked whether B-cell metabolism relates to these changes. Compared to pro B and small pre B cells, large pre B cells revealed the highest glucose uptake and ROS but not mitochondrial mass, whereas small pre B cells exhibited the lowest mitochondrial membrane potential. Small pre B cells from Rag1

Indexed as

Adenosine TriphosphateAnimalsB-LymphocytesBone Marrow CellsCalcium-Binding ProteinsCell LineDown-RegulationGene Knockdown TechniquesGenes, MitochondrialMetabolomeMice, Inbred C57BLMice, TransgenicMitochondriaOxygen ConsumptionPrecursor Cells, B-LymphoidReceptors, Antigen, B-CellAdenosine TriphosphateCalcium-Binding ProteinsReceptors, Antigen, B-Cell

Identifiers

PMID28524857
PMCPMC5520169
OpenAlexW2614577010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.