ArticleNature communications2017
Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 111 citations in OpenAlex.
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- Review
- Multicomponent Synthesis of C(8)-Substituted Purine Building Blocks of Peptide Nucleic Acids from Prebiotic Compounds.ChemistryOpen · 2024Article
- On the aqueous origins of the condensation polymers of life.Nature reviews. Chemistry · 2024Review
- Spontaneous Peptide Ligation Mediated by Cysteamine.JACS Au · 2024Article
- On the origin of life: an RNA-focused synthesis and narrative.RNA (New York, N.Y.) · 2023Article
- Biological Catalysis and Information Storage Have Relied onBiomolecules · 2023Review
- On the Origins of Enzymes: Phosphate-Binding Polypeptides Mediate Phosphoryl Transfer to Synthesize Adenosine Triphosphate.Journal of the American Chemical Society · 2023Article
- Prebiotic Synthesis of ATP: A Terrestrial Volcanism-Dependent Pathway.Life (Basel, Switzerland) · 2023Article
- Selective Synthesis of Lysine Peptides and the Prebiotically Plausible Synthesis of Catalytically Active Diaminopropionic Acid Peptide Nitriles in Water.Journal of the American Chemical Society · 2023Article
- Photochemistry of 2-thiooxazole: a plausible prebiotic precursor to RNA nucleotides.Physical chemistry chemical physics : PCCP · 2022Article
- Borate-guided ribose phosphorylation for prebiotic nucleotide synthesis.Scientific reports · 2022Article
- Protometabolism as out-of-equilibrium chemistry.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Review
- Prebiotic synthesis and triphosphorylation of 3'-amino-TNA nucleosides.Nature chemistry · 2022Article
- A Nonenzymatic Analog of Pyrimidine Nucleobase Biosynthesis.Angewandte Chemie (International ed. in English) · 2022Article
- A New Perspective on the Maillard Reaction and the Origin of Life.Journal of molecular evolution · 2021Article
- When Is a Reaction Network a Metabolism? Criteria for Simple Metabolisms That Support Growth and Division of Protocells.Life (Basel, Switzerland) · 2021Article
- Timescales for Prebiotic Photochemistry Under Realistic Surface Ultraviolet Conditions.Astrobiology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding prebiotic nucleotide synthesis is a long standing challenge thought to be essential to elucidating the origins of life on Earth. Recently, remarkable progress has been made, but to date all proposed syntheses account separately for the pyrimidine and purine ribonucleotides; no divergent synthesis from common precursors has been proposed. Moreover, the prebiotic syntheses of pyrimidine and purine nucleotides that have been demonstrated operate under mutually incompatible conditions. Here, we tackle this mutual incompatibility by recognizing that the 8-oxo-purines share an underlying generational parity with the pyrimidine nucleotides. We present a divergent synthesis of pyrimidine and 8-oxo-purine nucleotides starting from a common prebiotic precursor that yields the β-ribo-stereochemistry found in the sugar phosphate backbone of biological nucleic acids. The generational relationship between pyrimidine and 8-oxo-purine nucleotides suggests that 8-oxo-purine ribonucleotides may have played a key role in primordial nucleic acids prior to the emergence of the canonical nucleotides of biology.
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