ArticleRegenerative medicine2017
The role of myeloid cell-derived PDGF-B in neotissue formation in a tissue-engineered vascular graft.
Article in Regenerative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Modulating the platelet-mediated innate foreign body response to affect in situ vascular tissue engineering outcomes.NPJ Regenerative medicine · 2025Article
- Harnessing the potential of monocytes/macrophages to regenerate tissue-engineered vascular grafts.Cardiovascular research · 2024Review
- Hemodynamics and Wall Mechanics of Vascular Graft Failure.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Relationship between hematological parameters and bronchopulmonary dysplasia in premature infants.The Journal of international medical research · 2023Article
- Immunomodulation Strategies for the Successful Regeneration of a Tissue-Engineered Vascular Graft.Advanced healthcare materials · 2022Review
- Tissue engineered vascular grafts transform into autologous neovessels capable of native function and growth.Communications medicine · 2022Article
- Article
- Electrospun Tissue-Engineered Arterial Graft Thickness Affects Long-Term Composition and Mechanics.Tissue engineering. Part A · 2021Article
- Sex and Tamoxifen confound murine experimental studies in cardiovascular tissue engineering.Scientific reports · 2021Article
- Perivascular Adipose Tissue Regulates Vascular Function by Targeting Vascular Smooth Muscle Cells.Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- Endothelialization of arterial vascular grafts by circulating monocytes.Nature communications · 2020Article
- Imatinib attenuates neotissue formation during vascular remodeling in an arterial bioresorbable vascular graft.JVS-vascular science · 2020Article
- Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model.Journal of visualized experiments : JoVE · 2019Article
- Implantation of VEGF-functionalized cell-free vascular grafts: regenerative and immunological response.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
aimInflammatory myeloid lineage cells mediate neotissue formation in tissue-engineered vascular grafts, but the molecular mechanism is not completely understood. We examined the role of vasculogenic PDGF-B in tissue-engineered vascular graft neotissue development. MATERIALS &
methodsMyeloid cell-specific PDGF-B knockout mice (PDGF-KO) were generated using bone marrow transplantation, and scaffolds were implanted as inferior vena cava interposition grafts in either PDGF-KO or wild-type mice.
resultsAfter 2 weeks, grafts from PDGF-KO mice had more remaining scaffold polymer and less intimal neotissue development. Increased macrophage apoptosis, decreased smooth muscle cell proliferation and decreased collagen content was also observed.
conclusionMyeloid cell-derived PDGF contributes to vascular neotissue formation by regulating macrophage apoptosis, smooth muscle cell proliferation and extracellular matrix deposition.
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