ArticleThe Journal of physiology2017
Exercise-induced quadriceps muscle fatigue in men and women: effects of arterial oxygen content and respiratory muscle work.
Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04305873 (Effect of Exercise-induced Hypoxemia on Cytokine and Stress Hormone Responses Among Endurance-trained Athletes), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Exercise-induced Hypoxemia on Cytokine and Stress Hormone Responses Among Endurance-trained Athletes
Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Manipulation of mechanical ventilatory constraint during moderate intensity exercise does not influence dyspnoea in healthy older men and women.The Journal of physiology · 2019Trial
- Critical Narrative Review of the Applications of Near-Infrared Spectroscopy Technology in Sports Science.Sensors (Basel, Switzerland) · 2025Review
- The independent effects of age and sex in performance fatigability profile after a ramp incremental cycling test.European journal of applied physiology · 2025Article
- Predictive Threshold Value of the Breathing Reserve for the Decline in Cardiorespiratory Fitness Among the Healthy Middle-Aged Population.Journal of cardiovascular development and disease · 2025Article
- Breathing a low-density gas reduces respiratory muscle force development and marginally improves exercise performance in master athletes.European journal of applied physiology · 2024Article
- Similar effects on exercise performance following different respiratory muscle training programs in healthy young men.Scientific reports · 2023Article
- The effect of proportional assist ventilation on the electrical activity of the human diaphragm during exercise.Experimental physiology · 2023Article
- Sex differences in blood pressure and inactive limb blood flow responses during dynamic leg exercise with increased inspiratory muscle work.Nagoya journal of medical science · 2022Article
- Neuromuscular fatigability at high altitude: Lowlanders with acute and chronic exposure, and native highlanders.Acta physiologica (Oxford, England) · 2022Review
- Sex, gender and the pulmonary physiology of exercise.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Comprehensive evaluation of military training-induced fatigue among soldiers in China: A Delphi consensus study.Frontiers in public health · 2022Article
- The Effect of Hyperoxia on Central and Peripheral Factors of Arm Flexor Muscles Fatigue Following Maximal Ergometer Rowing in Men.Frontiers in physiology · 2022Article
- An integrative approach to the pulmonary physiology of exercise: when does biological sex matter?European journal of applied physiology · 2021Review
- Intercostal Muscles Oxygenation and Breathing Pattern during Exercise in Competitive Marathon Runners.International journal of environmental research and public health · 2021Article
- The Oxygen Cascade During Exercise in Health and Disease.Mayo Clinic proceedings · 2021Review
- Sex-Dependent Association Between Early Morning Ambulatory Blood Pressure Variations and Acute Mountain Sickness.Frontiers in physiology · 2021Article
- Association between physiological responses after exercise at low altitude and acute mountain sickness upon ascent is sex-dependent.Military Medical Research · 2020Article
- Anodal transcranial direct current stimulation reduces motor slowing in athletes and non-athletes.BMC neuroscience · 2020Article
- Neuromuscular fatigue during whole body exercise.Current opinion in physiology · 2019Article
- Sex differences in large conducting airway anatomy.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsHigh work of breathing and exercise-induced arterial hypoxaemia (EIAH) can decrease O ABSTRACT: Reducing the work of breathing or eliminating exercise-induced arterial hypoxaemia (EIAH) during exercise decreases the severity of quadriceps fatigue in men. Women have a greater work of breathing during exercise, dedicate a greater fraction of whole-body V̇O2 towards their respiratory muscles, and demonstrate EIAH, suggesting women may be especially susceptible to quadriceps fatigue. Healthy subjects (8 male, 8 female) completed three constant load exercise tests over 4 days. During the first (control) test, subjects exercised at ∼85% of maximum while arterial blood gases and work of breathing were assessed. Subsequent constant load exercise tests were iso-time and iso-work rate, but with EIAH prevented by inspiring hyperoxic gas or work of breathing reduced via a proportional assist ventilator (PAV). Quadriceps fatigue was assessed by measuring force in response to femoral nerve stimulation. For both sexes, quadriceps force was equally reduced after the control trial (-27 ± 2% baseline) and was attenuated with hyperoxia and PAV (-18 ± 1 and -17 ± 2% baseline, P < 0.01, respectively), with no sex difference. EIAH was similar between the sexes, and regardless of sex, subjects with the lowest oxyhaemoglobin saturation during the control test had the greatest quadriceps fatigue attenuation with hyperoxia (r
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.