Evidence map›Paper›PMID 28524154›Full record

ArticleCancer gene therapy2017

An analysis of the polymorphisms of the GLUT1 gene in urothelial cell carcinomas of the bladder and its correlation with p53, Ki67 and GLUT1 expressions.

C Xu, X Yang, Y Wang, N Ding, R Han, Y Sun, Y Wang

Abstract read
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In one paragraph

Article in Cancer gene therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Cigarette Smoking-RegulatedEnvironment & health (Washington, D.C.) · 2026
    Article
  2. The Effect of GLUT-1-XbaI G>T and HaeIII T>C Polymorphisms onMolecular imaging and radionuclide therapy · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

C XuDepartment of Colorectal Surgery, Tianjin Union Medicine Center, Tianjin, China.
X YangTianjin Institute of Urology, Department of Urology, Second Hospital of Tianjin Medical University, Tianjin, China.
Y WangTianjin Institute of Urology, Department of Urology, Second Hospital of Tianjin Medical University, Tianjin, China.
N DingTianjin Institute of Urology, Department of Urology, Second Hospital of Tianjin Medical University, Tianjin, China.
R HanTianjin Institute of Urology, Department of Urology, Second Hospital of Tianjin Medical University, Tianjin, China.
Y SunTianjin Institute of Urology, Department of Urology, Second Hospital of Tianjin Medical University, Tianjin, China.
Y WangDepartment of Anorectal Surgery, Hospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan City, Shandong Province, China.
Tianjin Medical University · CNSecond Hospital of Tianjin Medical University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frequencies of two glucose transporter 1 (GLUT1) single-nucleotide polymorphisms (SNPs) (XbaI G>T and HaeIII T>C) were studied with urothelial cell carcinomas of the bladder (UCC) and 204 normal persons. And the expression of the p53, Ki67 and GLUT1 was assayed by immunohistochemistry. The frequency of the TT genotype and T allele of the XbaI G>T SNP was decreased in the patients with UCC. The frequency of the CC genotype and C allele of the HaeIII T>C SNP was decreased in the patients with UCC. The GLUT1 XbaI genotype GG was more frequent in higher tumor stage and higher tumor grade patients. In the XbaI G>T SNP, the GG genotype was significantly related to higher Remmele immunoreactive score (IRS) of Ki67 and higher IRS of GLUT1. In conclusion, the TT genotype in XbaI G>T SNP and CC genotype of HaeIII T>C SNP may have protective effect in the carcinogenesis process of UCC. In the XbaI G>T SNP, the GG genotype of was positively related to tumor proliferation, glucose metabolism, tumor grade and stage. Therefore, the variant might become a possible proliferation-related prognostic factor for UCC.

Indexed as

Polymorphism, Single NucleotideAdultAgedAged, 80 and overAllelesCarcinomaCase-Control StudiesFemaleGene Expression Regulation, NeoplasticGene FrequencyGenetic Predisposition to DiseaseGenotypeGlucose Transporter Type 1HumansImmunohistochemistryKi-67 AntigenGlucose Transporter Type 1Ki-67 AntigenSLC2A1 protein, humanTumor Suppressor Protein p53

Identifiers

PMID28524154
OpenAlexW2615585835

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.