ArticleNutrients2017
Sleep-Promoting Effects and Possible Mechanisms of Action Associated with a Standardized Rice Bran Supplement.
Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Rice bran extract supplement improves sleep efficiency and sleep onset in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study.Scientific reports · 2019Trial
- Effects of Chronic Administration of a Standardized Rice Bran Supplement on Sleep Architecture and Profiles in Mice: A Comparative Study with a Hypnotic Drug Zolpidem.Journal of microbiology and biotechnology · 2025Article
- Impact of oryzanol plus femoston on efficacy, sleep quality, and quality of life in perimenopausal syndrome patients.American journal of translational research · 2025Article
- Optimization of Desalting Conditions for the Green SeaweedFoods (Basel, Switzerland) · 2024Article
- Xiaoyin-anshen formula alleviates psoriasis complicated by sleep disturbances by regulating melatonin, antioxidant enzymes, and pro-inflammatory cytokines in mice.Frontiers in pharmacology · 2024Article
- Effect of Black Pepper (Nutrients · 2022Article
- Fermented rice bran supplementation ameliorates obesity via gut microbiota and metabolism modification in female mice.Journal of clinical biochemistry and nutrition · 2022Article
- Arousal-Inducing Effect ofNutrients · 2021Article
- Effects of GABA/β-glucan supplements on melatonin and serotonin content extracted from natural resources.PloS one · 2021Article
- Standardized rice bran extract improves hepatic steatosis in HepG2 cells and ovariectomized rats.Nutrition research and practice · 2020Article
- Detection of Histamine Based on Gold Nanoparticles with Dual Sensor System of Colorimetric and Fluorescence.Foods (Basel, Switzerland) · 2020Article
- Hypnotic Effects ofNutrients · 2019Article
- A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice.Nutrients · 2019Article
- Hydrolysate Preparation with High Content of 5-Hydroxytryptophan from Liquid Egg Protein and Its Sleep-Potentiating Activity.Korean journal for food science of animal resources · 2017Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural sleep aids are becoming more popular due to the widespread occurrence of sleep disorders. The objective of this study was to assess the sleep-promoting effects of rice bran-a product that is considered as a functional ingredient. To evaluate the sleep-promoting effects of a standardized rice bran supplement (RBS), we employed a pentobarbital-induced sleep test and conducted analyses of sleep architecture. In addition, the effect of RBS on a caffeine-induced sleep disturbance was investigated. Oral administration of RBS (500 and 1000 mg/kg) produced a significant decrease in sleep latency and increase in sleep duration in pentobarbital-induced sleep in mice. Moreover, both RBS (1000 mg/kg) and doxepin hydrochloride (histamine H₁ receptor antagonist, 30 mg/kg) counteracted a caffeine-induced sleep disturbance in mice. In terms of sleep phases, RBS (500 mg/kg) promoted non-rapid eye movement sleep for the first 3 h following its administration. Lastly, we unveiled a possible mechanism for RBS action as the hypnotic effect of RBS was blocked by a histamine H₁ receptor agonist. The present study revealed sleep-promoting effects of RBS using various animal assays. Such effects seem to be mediated through the histaminergic system. Our findings suggest that RBS may be a promising natural aid for relieving sleep problems.
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