Evidence map›Paper›PMID 28524082›Full record

ArticleInternational journal of molecular sciences2017

Cellular Repair of DNA-DNA Cross-Links Induced by 1,2,3,4-Diepoxybutane.

Lisa N Chesner, Amanda Degner, Dewakar Sangaraju, Shira Yomtoubian, Susith Wickramaratne, Bhaskar Malayappan, Natalia Tretyakova, Colin Campbell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lisa N ChesnerDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA. ches0129@umn.edu.
Amanda DegnerDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA. degne013@umn.edu.
Dewakar SangarajuDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA. sanga016@umn.edu.
Shira YomtoubianDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA. syomtoubian@gmail.com.
Susith WickramaratneDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA. wickr011@umn.edu.
Bhaskar MalayappanDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA. bhaskarmal@gmail.com.
Natalia TretyakovaDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA. trety001@umn.edu.
Colin CampbellDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA. campb034@umn.edu.
University of Minnesota · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
TRAINING-PULMONARY CELL &MOLECULAR BIOLOGY &PHYSIOLOGYT32HL007741 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI DUDLEY, R. ADAMS, INGBAR, DAVID H · 1994 to 2023
$13.9M
DNA Protein Cross-Links:Cellular Effects and Repair MechanismsR01ES023350 · NIEHS · UNIVERSITY OF MINNESOTA · PI CAMPBELL, COLIN R, TRETYAKOVA, NATALIA Y · 2014 to 2023
$5.0M
DNA Cross-Linking By DiepoxybutaneR01CA100670 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TRETYAKOVA, NATALIA Y · 2003 to 2021
$3.5M
NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA100670NHLBI NIH HHS T32 HL007741NIEHS NIH HHS R01 ES023350
6 · The paper itself

Abstract

Xenobiotic-induced interstrand DNA-DNA cross-links (ICL) interfere with transcription and replication and can be converted to toxic DNA double strand breaks. In this work, we investigated cellular responses to 1,4-

Indexed as

AnimalsCell LineCricetinaeDNA Breaks, Double-StrandedDNA RepairEpoxy CompoundsFanconi AnemiaFanconi Anemia Complementation Group D2 ProteinXeroderma Pigmentosum Group A ProteindiepoxybutaneEpoxy CompoundsFanconi Anemia Complementation Group D2 ProteinXeroderma Pigmentosum Group A Protein1,2,3,4-diepoxybutaneChinese hamster lung fibroblastDNA double strand breakDNA repairFanconi anemiahomologous recombinationinterstrand DNA-DNA crosslinknucleotide excision repair

Identifiers

PMID28524082
PMCPMC5454995
OpenAlexW2616099454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.