Evidence map›Paper›PMID 28523947›Full record

ArticlePlatelets2018

Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y

Annachiara Mitrugno, Rachel A Rigg, Nicole B Laschober, Anh T P Ngo, Jiaqing Pang, Craig D Williams, Joseph E Aslan, Owen J T McCarty

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Platelets, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Platelet P2YBritish journal of pharmacology · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Role of platelets in regulating activated coagulation factor XI activity.American journal of physiology. Cell physiology · 2021
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Annachiara Mitrugnoa Department of Biomedical Engineering, School of Medicine , Oregon Health & Science University , Portland , OR , USA.
Rachel A Rigga Department of Biomedical Engineering, School of Medicine , Oregon Health & Science University , Portland , OR , USA.
Nicole B Laschobera Department of Biomedical Engineering, School of Medicine , Oregon Health & Science University , Portland , OR , USA.
Anh T P Ngoa Department of Biomedical Engineering, School of Medicine , Oregon Health & Science University , Portland , OR , USA.ORCID http://orcid.org/0000-0002-2179-6584
Jiaqing Panga Department of Biomedical Engineering, School of Medicine , Oregon Health & Science University , Portland , OR , USA.
Craig D Williamsd School of Pharmacy, Oregon State University , Portland , OR , USA.
Joseph E Aslane School of Medicine, Knight Cardiovascular Institute, Oregon Health & Science University , Portland , OR , USA.
Owen J T McCartya Department of Biomedical Engineering, School of Medicine , Oregon Health & Science University , Portland , OR , USA.
Oregon Health & Science University · USOregon State University · US

Funding

Characterization of Coagulation Factor-platelet Interactions: Role of FXIR01HL101972 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Owen J McCarty · 2010 to 2026
$8.5M
FXI and SepsisR01GM116184 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LUPU, FLOREA, MCCARTY, OWEN J · 2015 to 2018
$1.9M
NHLBI NIH HHS R01 HL101972NIGMS NIH HHS R01 GM116184
6 · The paper itself

Abstract

The release of ADP from platelet dense granules and its binding to platelet P2Y

Indexed as

AdenineBlood PlateletsCytoplasmic GranulesHumansPeptide FragmentsPlatelet ActivationPlatelet AggregationPurinergic P2Y Receptor AntagonistsReceptor, PAR-1Receptors, Purinergic P2Y12Valerates2,2-dimethylpropionic acid 3-(2-chloro-6-methylaminopurin-9-yl)-2-(2,2-dimethylpropionyloxymethyl)propyl esterAdenineP2RY12 protein, humanPeptide FragmentsPurinergic P2Y Receptor AntagonistsReceptor, PAR-1Receptors, Purinergic P2Y12thrombin receptor peptide (42-47)ValeratesADPdense granulesP2Y12platelets

Identifiers

PMID28523947
PMCPMC6155984
OpenAlexW2614354091

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.