ArticleEnvironmental science and pollution research international2017
Exogenous phosphatidylcholine supplementation retrieve aluminum-induced toxicity in male albino rats.
Article in Environmental science and pollution research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Nicotinamide mononucleotide improves spermatogenesis in aluminium-exposed mice by inhibiting NLRP3-mediated pyroptosis.PloS one · 2026Article
- The Role of Gut Bacteria and Plasma Metabolites in Predicting Post-Stroke Depression in Patients with Acute Ischemic Stroke.Current neuropharmacology · 2026Article
- The Antioxidant and Anti-Inflammatory Impacts of Purple and White Eggplants on Fertility and Expression of Fertility-Related Genes in Rats Treated With Aluminum Chloride.Journal of toxicology · 2024Article
- Lycopene alleviates lipopolysaccharide-induced testicular injury in rats by activating the PPAR signaling pathway to integrate lipid metabolism and the inflammatory response.Translational andrology and urology · 2023Article
- Review
- Endoplasmic reticulum stress and mitochondrial injury are critical molecular drivers of AlClHistochemistry and cell biology · 2022Article
- Exploring the Phosphatidylcholine in Inflammatory Bowel Disease: Potential Mechanisms and Therapeutic Interventions.Current pharmaceutical design · 2022Review
- Article
- Memory-Enhancing Effect of a Phytosome Containing the Combined Extract of Mulberry Fruit and Ginger in an Animal Model of Ischemic Stroke with Metabolic Syndrome.Oxidative medicine and cellular longevity · 2020Article
- Thymoquinone-PLGA-PVA Nanoparticles Ameliorate Bleomycin-Induced Pulmonary Fibrosis in Rats via Regulation of Inflammatory Cytokines and iNOS Signaling.Animals : an open access journal from MDPI · 2019Article
- Putative impacts of phytogenic additives to ameliorate lead toxicity in animal feed.Environmental science and pollution research international · 2019Review
- Bacopa phospholipid complex retrieves aluminum maltolate complex-induced oxidative stress and apoptotic alterations in the brain regions of albino rat.Environmental science and pollution research international · 2019Article
- L-α-Phosphatidylcholine attenuates mercury-induced hepato-renal damage through suppressing oxidative stress and inflammation.Environmental science and pollution research international · 2019Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the ameliorative potential of exogenous phosphatidylcholine (PC) against aluminum-induced toxicity in male albino rats. Four groups of rats were used for this study (N = 8): group I served as the control, group II (PC treated) received L-α-phosphatidylcholine (egg yolk-derived) 100 mg/kg bwt/day orally, group III (aluminum treated) received aluminum chloride 100 mg/kg bwt/day orally, and group VI (aluminum + PC treated) received similar oral dose of aluminum and PC (100 mg/kg bwt/day). Treatment was continued for 8 weeks. Results revealed that aluminum chloride treatment leading to a significant elevation in serum aspartate aminotransferase, serum alanine aminotransferase, urea, creatinine, malondialdehyde, serum cytokines (tumor necrosis factor-α, interleukin-6), and brain content of acetylcholine, as well as a significant reduction in serum-reduced glutathione, serum testosterone, and brain content of acetylcholinesterase. Moreover, aluminum administration caused significant histopathological alteration in liver, kidney, brain, testes, and epididymis. Co-treatment with exogenous PC resulted in significant improvement in intensity of histopathologic lesions, serum parameters, testosterone level, proinflammatory cytokines, and oxidative/antioxidative status. However, it does not affect the brain content of acetylcholine and acetylcholinesterase. Conclusively, treatment with exogenous PC can retrieve the adverse effect of aluminum toxicities through its antioxidative and anti-inflammatory properties.
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