ArticleEJNMMI research2017
First in-human radiation dosimetry of
Article in EJNMMI research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multimodal Assessment of the Inflammatory Atheromatous Plaque : Comparison Between 68Ga-NODAGA-RGD PET/CT, 18F-FDG PET/CT, MRI AND US
68Ga-NODAGA-RGD Cardiac PET in Patients With Acute Myocardial Infarction or Chronic Total Coronary Occlusion
Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- EANM guidance document: dosimetry for first-in-human studies and early phase clinical trials.European journal of nuclear medicine and molecular imaging · 2024Article
- Biodistribution, Dosimetry, and Pharmacokinetics ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Comparison of integrin αEuropean journal of hybrid imaging · 2023Article
- Comparison of absorbed dose extrapolation methods for mouse-to-human translation of radiolabelled macromolecules.EJNMMI research · 2022Article
- First-in-Human Study of [Diagnostics (Basel, Switzerland) · 2022Article
- Association between [Molecular biology reports · 2021Article
- Non-oncological applications of RGD-based single-photon emission tomography and positron emission tomography agents.European journal of nuclear medicine and molecular imaging · 2021Review
- Evaluation of [Frontiers in medicine · 2021Article
- Preclinical Evaluation and Dosimetry of [Molecular imaging and biology · 2020Article
- Head and neck tumors angiogenesis imaging withEJNMMI research · 2020Article
- Radiation dosimetry ofEJNMMI research · 2020Article
- First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonistEJNMMI research · 2018Article
- Screening and identification of key biomarkers in bladder carcinoma: Evidence from bioinformatics analysis.Oncology letters · 2018Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntegrin-targeting radiopharmaceuticals have potential broad applications, spanning from cancer theranostics to cardiovascular diseases. We have previously reported preclinical dosimetry results of
resultsThe body regions receiving the highest dose were urinary bladder, kidneys and choroid plexuses. For a 30-min voiding cycle, the EDs were 15.7 and 16.5 μSv/MBq according to ICRP60 and ICRP103, respectively. The extrapolation to female dosimetry resulted in organ absorbed doses 17% higher than those of male patients, on average. The 1-h voiding cycle extrapolation resulted in EDs of 19.3 and 19.8 μSv/MBq according to ICRP60 and ICRP103, respectively. A comparison is made with previous mouse dosimetry and with other human studies employing different RGD-based radiopharmaceuticals.
conclusionsAccording to ICRP60/ICRP103 recommendations, an injection of 200 MBq
trial registrationClinical trial.gov, NCT01608516.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.