Evidence map›Paper›PMID 28523434›Full record

ArticleProtein & cell2017

Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease.

Xiaowen Zheng, Feng Chen, Qian Zhang, Yulan Liu, Peng You, Shan Sun, Jiuxiang Lin, Ning Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein & cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaowen ZhengThe Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Feng ChenCentral Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Qian ZhangCentral Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Yulan LiuThe Department of Gastroenterology, Peking University People's Hospital, Beijing, 100044, China.
Peng YouThe Department of Gastroenterology, Peking University People's Hospital, Beijing, 100044, China.
Shan SunThe School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Jiuxiang LinThe Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China. jxlin@pku.edu.cn.ORCID http://orcid.org/0000-0002-3398-024X
Ning ChenThe Department of Gastroenterology, Peking University People's Hospital, Beijing, 100044, China. chenning79@139.com.ORCID http://orcid.org/0000-0002-4331-5649

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is an intestinal immune-dysfunctional disease worldwide whose prevalence increasing in Asia including China. It is a chronic disease of the gastrointestinal tract with unknown cause. Exosomes are small vesicles in various body fluids. They have diameters of 40-120 nm, and one of their functions is long-distance transfer of various substances. In this study, we investigated the contents of salivary exosomes in patients with IBD and in healthy controls to explore a new biomarker in patients with IBD. In this study, whole saliva was obtained from patients with IBD (ulcerative colitis (UC), n = 37; Crohn's disease (CD), n = 11) and apparently healthy individuals (HC, n = 10). Salivary exosomes were extracted from samples, and the proteins within the exosomes were identified by liquid chromatograph-mass spectrometer (LC-MS/MS). The results showed that more than 2000 proteins were detected in salivary exosomes from patients with IBD. Through gene ontology analysis, we found that proteasome subunit alpha type 7 (PSMA7) showed especially marked differences between patients with IBD and the healthy controls, in that its expression level was much higher in the CD and UC groups. This exosomal protein is related to proteasome activity and inflammatory responses. So we conclude that in this research, salivary exosomal PSMA7 was present at high levels in salivary exosomes from subjects with IBD. It can be a very promising biomarker to release the patients from the pain of colonoscopy.

Indexed as

AnimalsBiomarkersFemaleHumansInflammatory Bowel DiseasesMaleProteasome Endopeptidase ComplexSalivary Proteins and PeptidesBiomarkersProteasome Endopeptidase ComplexPSMA7 protein, humanSalivary Proteins and Peptidesexosomesinflammatory bowel diseaseproteomicsPSMA7

Identifiers

PMID28523434
PMCPMC5563283

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.