ArticlePediatric nephrology (Berlin, Germany)2017
Evaluation of height-dependent and height-independent methods of estimating baseline serum creatinine in critically ill children.
Article in Pediatric nephrology (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Renal Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.Pediatrics · 2022Pooled it
- Clinical presentations, treatments, and outcomes of pediatric lupus nephritis: a prospective cohort study from the Pediatric Nephrology Research Consortium.Pediatric nephrology (Berlin, Germany) · 2026Article
- Prevalence and risk factors for acute kidney injury at the diagnosis of juvenile idiopathic arthritis in children and its long-term implications for kidney health.Pediatric nephrology (Berlin, Germany) · 2026Article
- External Validation, Recalibration, and Extension of a Prediction Model of Early Acute Kidney Injury in Critically Ill Children Using Multicenter Data.Critical care explorations · 2026Article
- Prevalence and factors associated with acute kidney injury in children presenting to the emergency department with a first tonic-clonic seizure: an exploratory study.European journal of pediatrics · 2026Article
- Ultrasound cardiac output monitoring compared to the renal angina index for early prediction of pediatric acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Effects of induction-phase acute kidney injury and age at diagnosis on chronic kidney disease in pediatric acute lymphoblastic leukemia: a time-to-event cohort study.Clinical and experimental pediatrics · 2026Article
- Assessing kidney outcomes in childhood-onset lupus nephritis: role of National Institutes of Health-modified histological indices.Clinical and experimental pediatrics · 2026Article
- A novel age-norm-capped baseline serum creatinine approach for acute kidney injury diagnosis in critically Ill children: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- Evaluating the Impact of Acute Kidney Injury and Diabetic Ketoacidosis on Subsequent HbA1c in the First 36 Months in Children and Adolescents With New-Onset Type 1 Diabetes Mellitus.Journal of paediatrics and child health · 2025Article
- Kidney and blood pressure outcomes 11 years after pediatric critical illness and longitudinal impact of AKI: a prospective cohort study.Pediatric nephrology (Berlin, Germany) · 2025Article
- Vancomycin dosing in neonates: enhancing outcomes using population pharmacokinetics and simulation.Frontiers in antibiotics · 2025Article
- Long-Term Kidney Outcomes after Pediatric Acute Kidney Injury.Journal of the American Society of Nephrology : JASN · 2024Article
- Heart rate to identify non-febrile children with dehydration and acute kidney injury in emergency department: a prospective validation study.European journal of pediatrics · 2024Article
- Acute Kidney Injury in Children: A Focus for the General Pediatrician.Children (Basel, Switzerland) · 2024Review
- Association of continuous kidney replacement therapy timing and mortality in critically ill children.Pediatric nephrology (Berlin, Germany) · 2024Article
- Urinary biomarkers associated with acute kidney injury in pediatric mechanical circulatory support patients.Pediatric nephrology (Berlin, Germany) · 2024Article
- Acute kidney injury in infants hospitalized for viral bronchiolitis.European journal of pediatrics · 2023Article
- SARS-CoV-2 Infection in Children with Idiopathic Nephrotic Syndrome: A Multicentric Study.Indian pediatrics · 2023Article
- Prevalence and Risk Factors of Acute Kidney Injury in Hospitalized Children with Dengue Infection Using Kidney Disease Improving Global Outcomes Criteria.Indian journal of pediatrics · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundBaseline serum creatinine (bSCr) is required for diagnosing acute kidney injury (AKI). In children, bSCr is commonly defined as the lowest measurement within 3 months of admission. Measured values are often missing and estimating bSCr using height-based glomerular filtration rate (GFR) equations is problematic when height is unavailable.
methodsThis is a retrospective cohort study including 538 children admitted to the intensive care unit (ICU) between 2003 and 2005 at two centers in Canada, with measured bSCr, height, and ICU-SCr values. We evaluated the bias, accuracy, and precision of back-calculating bSCr from height-dependent and height-independent GFR equations. Agreement of AKI defined using measured and estimated bSCr was calculated. Multivariate analyses were performed to assess the impact of bSCr estimation methods on the association between AKI and ICU mortality, length of stay, and duration of mechanical ventilation.
resultsBoth methods underestimated bSCr by 1-3%, showed good accuracy (∼30% of patients with estimated bSCr within 10% of measured bSCr), but poor precision (wide 95% limits of agreement). The agreement between AKI defined by estimated versus measured bSCr was >80% (κ >0.5). The height-independent method performed best in children >13 years old; however, overall, both methods performed similarly across age subgroups. AKI was associated with longer stay, prolonged mechanical ventilation, and ICU mortality using measured and estimated bSCr.
conclusionsHeight-dependent and height-independent bSCr estimation methods were comparable. This may have significant implications for performing pediatric AKI research using large databases, and in clinical care to define AKI when height is unknown.
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