ArticleBrain and behavior2017
Interpersonal early-life trauma alters amygdala connectivity and sustained attention performance.
Article in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07309302 (Psychosocial Determinants and Impact of a Synchronous Remote Cognitive Remediation Program on Individuals With Post-Traumatic Stress Disorder.), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Psychosocial Determinants and Impact of a Synchronous Remote Cognitive Remediation Program on Individuals With Post-Traumatic Stress Disorder.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuropsychological Impact of Trauma-Related Mental Illnesses: A Systematic Review of Clinically Meaningful Results.Neuropsychology review · 2020Pooled it
- Brain Activity During the Gradual-Onset Continuous Performance Task in Adolescents: An Exploratory fMRI Study.Brain and behavior · 2026Article
- Neural activity is altered by childhood trauma exposure and varied by sex in typically developing youths during sustained attention-to-response tasks (SART).Neuropsychologia · 2025Article
- Increased anger and stress and heightened connectivity between IFG and vmPFC in victims during social interaction.Scientific reports · 2024Article
- Functional connectivity of amygdala subnuclei in PTSD: a narrative review.Molecular psychiatry · 2023Review
- Poorer Inhibitory Control Uniquely Contributes to Greater Functional Disability in Post-9/11 Veterans.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2023Article
- The functional relevance of visuospatial processing speed across the lifespan.Cognitive research: principles and implications · 2023Article
- Attention, attention! Posttraumatic stress disorder is associated with altered attention-related brain function.Frontiers in behavioral neuroscience · 2023Review
- A Framework to Advance Biomarker Development in the Diagnosis, Outcome Prediction, and Treatment of Traumatic Brain Injury.Journal of neurotrauma · 2022Review
- Self-reported experiences of discrimination in older black adults are associated with insula functional connectivity.Brain imaging and behavior · 2021Article
- Variable rather than extreme slow reaction times distinguish brain states during sustained attention.Scientific reports · 2021Article
- Evidence for a Specific Association Between Sustained Attention and Gait Speed in Middle-to-Older-Aged Adults.Frontiers in aging neuroscience · 2021Article
- Polysomnographic Sleep and Attentional Deficits in Traumatized North Korean Refugees.Nature and science of sleep · 2021Article
- Hippocampal and parahippocampal volumes vary by sex and traumatic life events in childrenJournal of psychiatry & neuroscience : JPN · 2020Article
- Interpersonal early life trauma is associated with increased cerebral perfusion and poorer memory performance in post-9/11 veterans.NeuroImage. Clinical · 2020Article
- Individual differences in sustained attention are associated with cortical thickness.Human brain mapping · 2019Article
- Trauma-related psychiatric and behavioral conditions are uniquely associated with sustained attention dysfunction.Neuropsychology · 2019Article
- The impact of interpersonal early life trauma on cardio-metabolic health in post-9/11 veterans.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019Article
- Tracking behavioral and neural fluctuations during sustained attention: A robust replication and extension.NeuroImage · 2018Article
- Interpersonal early-life trauma alters amygdala connectivity and sustained attention performance.Brain and behavior · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
introductionInterpersonal early life trauma (I-ELT) is associated with a myriad of functional impairments in adulthood, increased risk of drug addiction, and neuropsychiatric disorders. While deficits in emotional regulation and amygdala functioning are well characterized, deficits in general cognitive functioning have also been documented. However, the neural underpinnings of cognitive dysfunction in adults with a history of I-ELT and the potential relationship between amygdala-based functional connectivity and behavioral performance are currently poorly understood. This study examined how I-ELT affects the cognitive and neural mechanisms supporting sustained attention.
methodsA total of 66 Veterans (18 with and 48 without a history of I-ELT) completed a nonemotional sustained attention task during functional MRI.
resultsThe individuals with I-ELT showed significant impairments in sustained attention (i.e., higher error rates, greater response variability). This cohort exhibited increased amygdala functional connectivity with the prefrontal cortex and decreased functional connectivity with the parahippocampal gyrus when compared to those without I-ELT. These connections were significantly correlated with individual differences in sustained attention performance. Notably, classification analyses revealed that the pattern of amygdala connectivity across the whole brain was able to classify I-ELT status with 70% accuracy.
conclusionThese results provide evidence of a lasting negative impact for those with a history of I-ELT on sustained attention ability. They also highlight a critical role for amygdala functioning in cognitive control and sustained attention for those with a history of I-ELT, which may underlie the observed attention deficits in clinical assessments and cognitive tests involving both emotional and nonemotional stimuli.
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