ArticleBrain and behavior2017
Complex regional pain syndrome: The matter of white matter?
Article in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Diagnostic Criteria and Technical Evaluation of Complex Regional Pain Syndrome: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Article
- Review
- Somatotopic disruption of the functional connectivity of the primary sensorimotor cortex in complex regional pain syndrome type 1.Human brain mapping · 2023Article
- Imaging Modalities and Their Findings in Patients With Complex Regional Pain Syndrome: A Review.Cureus · 2023Review
- Effect and mechanisms of exercise for complex regional pain syndrome.Frontiers in molecular neuroscience · 2023Review
- [Complex regional pain syndrome-An update].Schmerz (Berlin, Germany) · 2022Article
- [Complex regional pain syndrome-An update].Der Nervenarzt · 2021Article
- On the Relationship Between White Matter Structure and Subjective Pain. Lessons From an Acute Surgical Pain Model.Frontiers in human neuroscience · 2020Article
- Complex regional pain syndrome: The matter of white matter?Brain and behavior · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionMany central pathophysiological aspects of complex regional pain syndrome (CRPS) are still unknown. Although brain-imaging studies are increasingly supporting the contribution of the central nervous system to the generation and maintenance of the CRPS pain, the brain's white-matter alterations are seldom investigated.
methodsIn this study, we used diffusion tensor imaging to explore white-matter changes in twelve CRPS-type-1 female patients suffering from chronic right upper-limb pain compared with twelve healthy control subjects.
resultsTract-based spatial-statistics analysis revealed significantly higher mean diffusivity, axial diffusivity, and radial diffusivity in the CRPS patients, suggesting that the structural connectivity is altered in CRPS. All these measures were altered in the genu, body, and splenium of corpus callosum, as well as in the left anterior and posterior and the right superior parts of the corona radiata. Axial diffusivity was significantly correlated with clinical motor symptoms at whole-brain level, supporting the physiological significance of the observed white-matter abnormalities.
conclusionsAltogether, our findings further corroborate the involvement of the central nervous system in CRPS.
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