ArticleNeural plasticity2017
Mechanisms Underlying the Antidepressant Response of Acupuncture via PKA/CREB Signaling Pathway.
Article in Neural plasticity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Effect of acupuncture on menopausal depressive disorder and serum hormone levels: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- A Multicenter, Randomized, Controlled Trial of Electroacupuncture for Perimenopause Women with Mild-Moderate Depression.BioMed research international · 2018Trial
- Possible antidepressant mechanism of acupuncture: targeting neuroplasticity.Frontiers in neuroscience · 2025Review
- Acupuncture may play a key role in anti-depression through various mechanisms in depression.Chinese medicine · 2024Review
- Review
- Acupuncture Ameliorates Depression-Like Behaviors Through Modulating the Neuroinflammation Mediated by TLR4 Signaling Pathway in Rats Exposed to Chronic Restraint Stress.Molecular neurobiology · 2024Article
- Electroacupuncture alleviated depression-like behaviors in ventromedial prefrontal cortex of chronic unpredictable mild stress-induced rats: Increasing synaptic transmission and phosphorylating dopamine transporter.CNS neuroscience & therapeutics · 2023Article
- Neural plasticity and depression treatment.IBRO neuroscience reports · 2023Article
- Involvement of purinergic P2Y1R in antidepressant-like effects of electroacupuncture treatment on social isolation stress mice.Purinergic signalling · 2023Article
- Electroacupuncture Zusanli (ST36) Relieves Somatic Pain in Colitis Rats by Inhibiting Dorsal Root Ganglion Sympathetic-Sensory Coupling and Neurogenic Inflammation.Neural plasticity · 2023Article
- cAMP/PKA-CREB-BDNF signaling pathway in hippocampus of rats subjected to chemically-induced phenylketonuria.Metabolic brain disease · 2022Article
- Magnetic Resonance Imaging Studies on Acupuncture Therapy in Depression: A Systematic Review.Frontiers in psychiatry · 2021Review
- An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Xiong-Pi-Fang in Treating Coronary Heart Disease with Depression.Frontiers in pharmacology · 2021Article
- Asiaticoside produces an antidepressant‑like effect in a chronic unpredictable mild stress model of depression in mice, involving reversion of inflammation and the PKA/pCREB/BDNF signaling pathway.Molecular medicine reports · 2020Article
- Optimization of food deprivation and sucrose preference test in SD rat model undergoing chronic unpredictable mild stress.Animal models and experimental medicine · 2020Article
- Mechanisms Underlying the Antidepressant Effect of AcupunctureFrontiers in behavioral neuroscience · 2020Article
- The Neuroprotective Effect of L-Stepholidine on Methamphetamine-Induced Memory Deficits in Mice.Neurotoxicity research · 2019Article
- Transcriptome Analysis on Maternal Separation Rats With Depression-Related Manifestations Ameliorated by Electroacupuncture.Frontiers in neuroscience · 2019Article
- Effect of Electroacupuncture on Reuptake of Serotonin via miRNA-16 Expression in a Rat Model of Depression.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Signal Transduction Pathways of Acupuncture for Treating Some Nervous System Diseases.Evidence-based complementary and alternative medicine : eCAM · 2019Review
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein kinase A (PKA)/cAMP response element-binding (CREB) protein signaling pathway, contributing to impaired neurogenesis parallel to depressive-like behaviors, has been identified as the crucial factor involved in the antidepressant response of acupuncture. However, the molecular mechanisms associated with antidepressant response of acupuncture, neurogenesis, and depressive-like behaviors ameliorating remain unexplored. The objective was to identify the mechanisms underlying the antidepressant response of acupuncture through PKA signaling pathway in depression rats by employing the PKA signaling pathway inhibitor H89 in in vivo experiments. Our results indicated that the expression of hippocampal PKA-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.