ReviewFrontiers in plant science2017
Harnessing Plant Biodiversity for the Discovery of Novel Anticancer Drugs Targeting Microtubules.
Review in Frontiers in plant science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- Polytrichastrum alpinum methanol extract induces cell cycle arrest and apoptosis in mammary tumor cells of companion dogs.Genes & genomics · 2026Article
- Comprehensive scientific insights on plant inspired nano therapeutics as the missing piece of the breast cancer puzzle.Discover nano · 2026Review
- Biomolecule Detection Methods Based on Nanoparticle Approaches.ACS omega · 2026Review
- Extract of endophytic fungus Cepalotheca foveolata (N11) inhibits lytic bacteriophage: a study on activity, cytotoxicity, and chemical profiling.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Molecular Targets of Plant-based Alkaloids and Polyphenolics in Liver and Breast Cancer- An Insight into Anticancer Drug Development.Anti-cancer agents in medicinal chemistry · 2025Review
- Endophytic fungi: A future prospect for breast cancer therapeutics and drug development.Heliyon · 2024Review
- Identification of 3-((4-Hydroxyphenyl)amino)propanoic Acid Derivatives as Anticancer Candidates with Promising Antioxidant Properties.Molecules (Basel, Switzerland) · 2024Article
- Regulation of gene expression by modulating microRNAs through Epigallocatechin-3-gallate in cancer.Molecular biology reports · 2024Review
- Antioxidant, Anti-Inflammatory and Anti-Proliferative Properties ofPlants (Basel, Switzerland) · 2023Article
- First report on isolation ofBiotechnology reports (Amsterdam, Netherlands) · 2022Article
- Evaluation of the target-specific therapeutic potential of herbal compounds for the treatment of cancer.Molecular diversity · 2022Review
- Natural Products That Changed Society.Biomedicines · 2021Review
- Modified heptapeptide from tau binds both tubulin and microtubules.Thoracic cancer · 2020Article
- Alteration of cell junctions during viral infection.Thoracic cancer · 2020Review
- Environmental pollutants damage airway epithelial cell cilia: Implications for the prevention of obstructive lung diseases.Thoracic cancer · 2020Review
- Ricinus communis L. fruit extract inhibits migration/invasion, induces apoptosis in breast cancer cells and arrests tumor progression in vivo.Scientific reports · 2019Article
- Spectroscopic Technique-Based Comparative Investigation on the Interaction of Theaflavins with Native and Glycated Human Serum Albumin.Molecules (Basel, Switzerland) · 2019Article
- Costunolide Inhibits the Growth of OAW42-A Multidrug-Resistant Human Ovarian Cancer Cells by Activating Apoptotic and Autophagic Pathways, Production of Reactive Oxygen Species (ROS), Cleaved Caspase-3 and Cleaved Caspase-9.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Review
- Antitumor Activity of Asiaticoside Against Multiple Myeloma Drug-Resistant Cancer Cells Is Mediated by Autophagy Induction, Activation of Effector Caspases, and Inhibition of Cell Migration, Invasion, and STAT-3 Signaling Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microtubule cytoskeleton plays a critical role in a wide range of cellular activities and has been shown to be a highly effective target for the treatment of human malignancies. Despite the recent focus on proteomics and high-throughput profiling, it is clear that analysis of plant extracts has yielded several highly efficacious microtubule-targeting agents (MTAs) currently in clinical use, as well as agents in the current pipeline with promising efficacy. To date, a large proportion of the world's plant biodiversity remains untapped by the pharmaceutical industry, presenting a major opportunity for the discovery of novel pharmacologically active lead compounds. Because plants contain an astonishing array of structurally diverse molecules, they represent an ideal source for the discovery of novel MTA leads. To demonstrate the importance of searching for novel bioactive compounds across the plant kingdom, herein, we summarize the discovery and development of plant-derived MTAs and discuss the challenges associated with searching for novel bioactive compounds from plants. We propose potential solutions to these problems with the aim of facilitating further exploration and identification of novel MTAs from plant biodiversity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.