ReviewCanadian respiratory journal2017
Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension.
Review in Canadian respiratory journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- High-flow nasal oxygen versus conventional nasal cannula for gastroscopy with sedation in elderly patients at high altitudes: a partially-blinded randomized controlled trial in Tibet, China.BMC anesthesiology · 2026Trial
- Safety and Efficacy of Therapeutic Erythrocytapheresis Treatment in Chronic Mountain Sickness Patients in Shigatse, Tibet, China.Medical science monitor : international medical journal of experimental and clinical research · 2020Trial
- Association of High-Altitude Polycythemia with JAK2V617F Mutation in Pakistani Population.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Article
- Adjustment Criteria for Air-Quality Standards by Altitude: A Scoping Review with Regulatory Overview.International journal of environmental research and public health · 2025Article
- Reframing SpOFrontiers in physiology · 2025Review
- Sleep Quality Among Pilgrims at High Altitude: A Cross-Sectional Study From Gosaikunda Lake, Nepal (4380 m).Cureus · 2024Article
- A prospective, self-controlled study of sub-plateau heart rate variability in healthy adults.Frontiers in physiology · 2024Article
- Geo-authentic Tibetan medicine: a traditional pharmacological resource for promoting human health and wellness.Frontiers in pharmacology · 2024Review
- Decreased plasma levels of the brain-derived neurotrophic factor correlate with right heart congestion in pulmonary arterial hypertension.ERJ open research · 2023Article
- Continuous Hypobaric Hypoxia may Promote Atherosclerosis Progression in Apolipoprotein E-deficient Mice.International journal of medical sciences · 2023Article
- Mean corpuscular haemoglobin concentration (MCHC): a new biomarker for high-altitude pulmonary edema in the Ecuadorian Andes.Scientific reports · 2022Article
- Protective effect of salidroside on lung tissue in rats exposed rapidly to high altitude.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2022Article
- [Variability of hemoglobin and hematocrit determined in blood gas equipment].Revista medica del Instituto Mexicano del Seguro Social · 2022Article
- Deletion of classical transient receptor potential 1, 3 and 6 alters pulmonary vasoconstriction in chronic hypoxia-induced pulmonary hypertension in mice.Frontiers in physiology · 2022Article
- [Chronic exposure to altitude. Clinical characteristics and diagnosis].Archivos de cardiologia de Mexico · 2021Article
- miR‑205‑3p promotes lung cancer progression by targeting APBB2.Molecular medicine reports · 2021Article
- Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension.Antioxidants & redox signaling · 2021Review
- Intermittent short-duration reoxygenation protects against simulated high altitude-induced pulmonary hypertension in rats.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Article
- Iron deficiency is a possible risk factor causing right heart failure in Tibetan children living in high altitude area.Medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With rising altitude the partial pressure of oxygen falls. This phenomenon leads to hypobaric hypoxia at high altitude. Since more than 140 million people permanently live at heights above 2500 m and more than 35 million travel to these heights each year, understanding the mechanisms resulting in acute or chronic maladaptation of the human body to these circumstances is crucial. This review summarizes current knowledge of the body's acute response to these circumstances, possible complications and their treatment, and health care issues resulting from long-term exposure to high altitude. It furthermore describes the characteristic mechanisms of adaptation to life in hypobaric hypoxia expressed by the three major ethnic groups permanently dwelling at high altitude. We additionally summarize current knowledge regarding possible treatment options for hypoxia-induced pulmonary hypertension by reviewing in vitro, rodent, and human studies in this area of research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.