Evidence map›Paper›PMID 28522916›Full record

Observational studyWorld journal of gastroenterology2017

Early hepatitis B viral DNA clearance predicts treatment response at week 96.

Xiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Bin Gu, Li-Hua Hu, Zhong-Tian Peng, Bin Chen, Yuan-Lin Xie, Huan-Yu Gong, Xiao-Xuan Hu and 9 more

Open access · hybridAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Xiao-Yu FuXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
De-Ming TanXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Cui-Mei LiuXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Bin GuXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Li-Hua HuXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Zhong-Tian PengXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Bin ChenXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Yuan-Lin XieXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Huan-Yu GongXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Xiao-Xuan HuXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Lian-Hui YaoXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Xiao-Ping XuXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Zheng-Yuan FuXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Lang-Qiu HeXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Si-Hai LiXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Yun-Zhu LongXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
De-Hui LiXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Ji-Long GuXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Shi-Fang PengXiao-Yu Fu, De-Ming Tan, Cui-Mei Liu, Shi-Fang Peng, Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate whether hepatitis viral DNA load at 24 wk of treatment predicts response at 96 wk in patients with chronic hepatitis B.

methodsA total of 172 hepatitis B envelope antigen (HBeAg)-positive chronic hepatitis B patients who received initial treatment at 16 tertiary hospitals in Hunan Province, China were enrolled in this study. All patients received conventional doses of lamivudine and adefovir dipivoxil, telbivudine, entecavir dispersible tablets, or entecavir tablets for 96 wk. Patients who used other antiviral drugs or antitumor and immune regulation therapy were excluded. Patients were stratified into three groups according to their viral DNA load at 24 wk: < 10 IU/mL (group 1), 10-10

resultsThe rates of conversion to HBeAg negative status and HBeAg seroconversion rates were 53.7% and 51.9%, respectively, in group 1; 35.21% and 32.39% in group 2; and 6.38% and 6.38% in group 3. The receiver operating characteristic curves for the three subgroups revealed that the lowest DNA load (< 10 IU/mL) was better correlated with response at 96 wk than a higher DNA load (10-10

conclusionHepatitis B viral DNA load at 24 wk of antiviral treatment in patients with chronic hepatitis B is a predictor of the viral load and response rate at 96 wk.

Indexed as

AdenineAdultAntiviral AgentsArea Under CurveChinaDNA, ViralFemaleGuanineHepatitis B, ChronicHepatitis B e AntigensHepatitis B virusHumansLamivudineMaleMiddle AgedOrganophosphonatesadefovir dipivoxilAdenineAntiviral AgentsDNA, ViralentecavirGuanineHepatitis B e AntigensLamivudineOrganophosphonatesTelbivudineThymidineChronic hepatitis BHepatitis B antibodiesHepatitis B antigensHepatitis B virusHepatitis B virus DNANucleoside analogueViral DNA load

Identifiers

PMID28522916
PMCPMC5413793
OpenAlexW2608250537

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.