Evidence map›Paper›PMID 28522911›Full record

ArticleWorld journal of gastroenterology2017

Study of the effects of nesfatin-1 on gastric function in obese rats.

Guo-Tao Yang, Hong-Ying Zhao, Yu Kong, Ning-Ning Sun, Ai-Qin Dong

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Effect of glutamine use on the formation of intestinal neomucosa on peritoneal surface in rats.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022
    Article
  3. "Sibling" battle or harmony: crosstalk between nesfatin-1 and ghrelin.Cellular and molecular life sciences : CMLS · 2022
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Current Understanding of the Role of Nesfatin-1.Journal of the Endocrine Society · 2018
    Review
  10. Novel transmitters in brain stem vagal neurocircuitry: new players on the pitch.American journal of physiology. Gastrointestinal and liver physiology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Guo-Tao YangGuo-Tao Yang, Ai-Qin Dong, Department of Third Neurology, Cangzhou Central Hospital, Cangzhou Clinical Medical School of Hebei Medical University, Cangzhou 061001, Hebei Province, China.
Hong-Ying ZhaoGuo-Tao Yang, Ai-Qin Dong, Department of Third Neurology, Cangzhou Central Hospital, Cangzhou Clinical Medical School of Hebei Medical University, Cangzhou 061001, Hebei Province, China.
Yu KongGuo-Tao Yang, Ai-Qin Dong, Department of Third Neurology, Cangzhou Central Hospital, Cangzhou Clinical Medical School of Hebei Medical University, Cangzhou 061001, Hebei Province, China.
Ning-Ning SunGuo-Tao Yang, Ai-Qin Dong, Department of Third Neurology, Cangzhou Central Hospital, Cangzhou Clinical Medical School of Hebei Medical University, Cangzhou 061001, Hebei Province, China.
Ai-Qin DongGuo-Tao Yang, Ai-Qin Dong, Department of Third Neurology, Cangzhou Central Hospital, Cangzhou Clinical Medical School of Hebei Medical University, Cangzhou 061001, Hebei Province, China.
Cangzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the effects of nesfatin-1 on gastric function in obese rats.

methodsThe obese rat model was induced by a high-fat diet. The gastric emptying rate and gastric acid secretory capacity of the rats were determined after treatment with different drug concentrations of nesfatin-1 and administration routes. Based on this, the expression of H+/K+-ATPase was measured using RT-PCR and western blot to preliminarily explore the mechanism of gastric acid secretion changes.

resultsBody weight, body length, and Lee's index of the rats significantly increased in the high-fat diet-induced obese rat model. Two hours after lateral intracerebroventricular injection of nesfatin-1, the gastric emptying rate and gastric acid secretory capacity of rats decreased. Four hours after injection, both were restored to normal levels. In addition, the expression of H+/K+-ATPase decreased and moved in line with changes in gastric acid secretory capacity. This

conclusionThrough this research, we provide a theoretical basis for further studies on nesfatin-1, a potential anti-obesity drug.

Indexed as

AnimalsAnti-Obesity AgentsCalcium-Binding ProteinsDiet, High-FatDisease Models, AnimalDNA-Binding ProteinsDose-Response Relationship, DrugGastric AcidGastric EmptyingGastric MucosaH(+)-K(+)-Exchanging ATPaseInjections, IntravenousInjections, IntraventricularNerve Tissue ProteinsNucleobindinsObesityAnti-Obesity AgentsCalcium-Binding ProteinsDNA-Binding ProteinsH(+)-K(+)-Exchanging ATPaseNerve Tissue ProteinsNucb1 protein, ratNucleobindinsRNA, MessengerH+/K+-ATPaseNesfatin-1Obesity

Identifiers

PMID28522911
PMCPMC5413788
OpenAlexW2609029552

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.