ArticleScientific reports2017
Diagnosing congenital malaria in a high-transmission setting: clinical relevance and usefulness of P. falciparum HRP2-based testing.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Management of malaria in newborns: a systematic review.BMC infectious diseases · 2025Pooled it
- Prevalence, predictors and adverse perinatal outcomes of placental malaria in sub-Saharan Africa: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2025Pooled it
- Risk of malaria in young children after periconceptional iron supplementation.Maternal & child nutrition · 2021Trial
- Congenital Malaria in Non-Endemic Settings: A Literature Review and Update on Diagnosis and Management.Journal of travel medicine · 2026Article
- Prevalence of submicroscopic congenital malaria and associated risk factors in an area of low endemicity of Guatemala.Malaria journal · 2025Article
- Current update on malaria in pregnancy: a systematic review.Tropical diseases, travel medicine and vaccines · 2025Review
- Plasmodium falciparum neonatal malaria with atypical presentation: a case series from southwestern Ethiopia.Malaria journal · 2024Article
- Diagnostic value of rapid test for malaria among febrile neonates in a tertiary hospital in North-East Nigeria: a prospective cross-sectional study.Archives of disease in childhood · 2023Article
- Associations between prenatal malaria exposure, maternal antibodies at birth, and malaria susceptibility during the first year of life in Burkina Faso.Infection and immunity · 2023Article
- Molecular surveillance of Plasmodium falciparum drug-resistance markers in Vietnam using multiplex amplicon sequencing (2000-2016).Scientific reports · 2023Article
- Altered Offspring Immunity in Maternal Parasitic Infections.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- Accuracy of SD Malaria Ag P.f/Pan® as a rapid diagnostic test in French Amazonia.Malaria journal · 2021Article
- Asymptomatic malaria and anaemia among pregnant women during high and low malaria transmission seasons in Burkina Faso: household-based cross-sectional surveys in Burkina Faso, 2013 and 2017.Malaria journal · 2021Article
- Malaria Rapid Diagnostic Tests: Literary Review and Recommendation for a Quality Assurance, Quality Control Algorithm.Diagnostics (Basel, Switzerland) · 2021Review
- Genetic variation in the immune system and malaria susceptibility in infants: a nested case-control study in Nanoro, Burkina Faso.Malaria journal · 2021Article
- Congenital Malaria in a 2-Day-Old Neonate: A Case Report and Literature Review.Case reports in infectious diseases · 2021Article
- The immune response to malaria in utero.Immunological reviews · 2020Review
- Congenital Malaria and Its Associated Factors at Issaka Gazobi Maternity of Niamey in Niger.International journal of pediatrics · 2020Article
- Congenital Malaria in Newborns Presented at Tororo General Hospital in Uganda: A Cross-Sectional Study.The American journal of tropical medicine and hygiene · 2019Article
- Modulation of innate immune responses at birth by prenatal malaria exposure and association with malaria risk during the first year of life.BMC medicine · 2018Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital malaria diagnosis is challenging due to frequently observed low parasite density infections, while their clinical relevance during early infancy is not well characterized. In Nanoro health district (Burkina Faso), we determined the prevalence of congenital malaria by real-time quantitative PCR and we assessed the performance of rapid diagnosis test (RDT) and light microscopy (LM) to detect Plasmodium falciparum infections in cord-blood samples. In addition, we examined the usefulness of P. falciparum Histidine Rich Protein2 (PfHRP2) as surrogate biomarker of infection and explored association between congenital malaria and clinical outcomes. A prevalence of congenital malaria by qPCR of 4% (16/400) was found, which increased to 10% among newborns from mothers infected at delivery. RDT and LM showed poor performances indicating limited utility for congenital malaria screening in cord blood. Because PfHRP2 detection in cord blood could be affected by transplacental passage of parasite antigens, PfHRP2 might not be used as a surrogate biomarker of congenital malaria infections. There was no evidence of a significant clinical impact of congenital malaria on infant's health from birth to 59 days of life. Case control studies including long-term follow up may provide additional understanding on the relevance of neonatal malaria infections.
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