ArticleScientific reports2017
Near-Infrared Heptamethine Cyanine Based Iron Oxide Nanoparticles for Tumor Targeted Multimodal Imaging and Photothermal Therapy.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 58 citations in OpenAlex.
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- Ultra-compact quintuple-band terahertz metamaterial biosensor for enhanced blood cancer diagnostics.PloS one · 2025Article
- A Multifunctional, Highly Biocompatible, and Double-Triggering Caramelized Nanotheranostic System Loaded with FeInternational journal of nanomedicine · 2023Article
- A Rare-Earth Near-Infrared Nanoprobe for the Identification of Small Cell Lung Cancer.International journal of nanomedicine · 2023Article
- Cancer Diagnosis Using Terahertz-Graphene-Metasurface-Based Biosensor with Dual-Resonance Response.Nanomaterials (Basel, Switzerland) · 2022Article
- Advanced iron oxide nanotheranostics for multimodal and precision treatment of pancreatic ductal adenocarcinoma.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022Review
- Heptamethine Cyanine-Based Application for Cancer Theranostics.Frontiers in pharmacology · 2021Review
- Florescence Imaging Lung Cancer with a Small Molecule MHI-148.Journal of fluorescence · 2020Article
- Near Infrared Fluorescent Nanoplatform for Targeted Intraoperative Resection and Chemotherapeutic Treatment of Glioblastoma.ACS nano · 2020Article
- Shell-Free Copper Indium Sulfide Quantum Dots Induce ToxicityNano letters · 2020Article
- Photophysics and photochemistry of NIR absorbers derived from cyanines: key to new technologies based on chemistry 4.0.Beilstein journal of organic chemistry · 2020Review
- Synthesis, Principles, and Properties of Magnetite Nanoparticles for In Vivo Imaging Applications-A Review.Pharmaceutics · 2019Review
- Synergistic combination of chemo‑phototherapy based on temozolomide/ICG‑loaded iron oxide nanoparticles for brain cancer treatment.Oncology reports · 2019Article
- PEG-coated and Gd-loaded fluorescent silica nanoparticles for targeted prostate cancer magnetic resonance imaging and fluorescence imaging.International journal of nanomedicine · 2019Article
- Doxorubicin/Cisplatin-Loaded Superparamagnetic Nanoparticles As A Stimuli-Responsive Co-Delivery System For Chemo-Photothermal Therapy.International journal of nanomedicine · 2019Article
- MHI-148 Cyanine Dye Conjugated Chitosan Nanomicelle with NIR Light-Trigger Release Property as Cancer Targeting Theranostic Agent.Molecular imaging and biology · 2018Article
- A Novel Bimodal Imaging Agent Targeting HER2 Molecule of Breast Cancer.Journal of immunology research · 2018Article
- Broadband absorption and enhanced photothermal conversion property of octopod-like Ag@AgScientific reports · 2017Article
- A synthetic urinary probe-coated nanoparticles sensitive to fibroblast activation protein α for solid tumor diagnosis.International journal of nanomedicine · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Near-infrared fluorescent (NIRF) imaging modality holds great promise for tumor detection and offers several advantages of bioimaging, such as high tissue penetration with less background scattering. The disadvantage of NIRF bioimaging is that it has very low spatial resolution. Thus, the combination of NIRF with magnetic resonance imaging (MRI) is a good option because MRI can provide anatomical information with a higher resolution. Heptamethine cyanine dye (MHI-148) has been reported to have tumor-targeting capability which was used here as the NIRF agent. DSPE-SPION nanoparticles were synthesized by the solvent hydration method and conjugated with MHI-148 dye to form a MRI/NIRF dual imaging probe. The size and charge of the MHI-DSPE-SPION were found to be about 84 ± 6 nm and 3.7 mV by DLS & Zeta Potential analysis. In vivo MRI of the SCC7 tumor showed an enhanced accumulation of MHI-DSPE-SPION, peaking at day 1, compared to 4 hrs with the control DSPE-SPION. An in vivo photothermal tumor reduction study was done on the SCC7 tumor of BALB/c nude mice. Tumor reduction study showed complete tumor removal after 8 days. In conclusion, MHI-DSPE-SPION can be used as a cancer theranostics material because it provides MRI-optical imaging capabilities and the photothermal therapy (PTT) effect.
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