ArticleScientific reports2017
Reactivity in the human retinal microvasculature measured during acute gas breathing provocations.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Effect of chronic high-altitude hypoxia on retinal vascular phenotype, choroidal and retinal vasoreactivity in Peruvian highlanders.Experimental physiology · 2026Article
- Red Blood Cell Distribution and Volume Changes at Capillary Junctions in the Living Human Retina.Investigative ophthalmology & visual science · 2025Article
- Cerebrovascular Function in Sporadic and Genetic Cerebral Small Vessel Disease.Annals of neurology · 2025Article
- pH in the vertebrate retina and its naturally occurring and pathological changes.Progress in retinal and eye research · 2025Review
- Association of Cerebrovascular Reactivity With 1-Year Imaging and Clinical Outcomes in Small Vessel Disease: An Observational Cohort Study.Neurology · 2024Observational
- Measurement of retinal blood flow precision in the human eye with multimodal adaptive optics imaging.Biomedical optics express · 2024Article
- Validation of an automated method for studying retinal capillary blood flow.Biomedical optics express · 2024Article
- Repeatability and Comparability of Retinal Blood Vessel Caliber Measurements by OCTA.Vision (Basel, Switzerland) · 2023Article
- Flow Heterogeneity and Factors Contributing to the Variability in Retinal Capillary Blood Flow.Investigative ophthalmology & visual science · 2023Article
- Evolution of adaptive optics retinal imaging [Invited].Biomedical optics express · 2023Review
- Mapping the human parafoveal vascular network to understand flow variability in capillaries.PloS one · 2023Article
- A stronger association of diabetes mellitus with impaired hyperaemia using a novel ECG-gated device compared with peripheral arterial tonometry.International ophthalmology · 2022Article
- Measuring Temporal and Spatial Variability of Red Blood Cell Velocity in Human Retinal Vessels.Investigative ophthalmology & visual science · 2021Article
- Imaging the Retinal Vasculature.Annual review of vision science · 2021Review
- Optical Coherence Tomography Angiography-Derived Flux As a Measure of Physiological Changes in Retinal Capillary Blood Flow.Translational vision science & technology · 2021Article
- Past, present and future role of retinal imaging in neurodegenerative disease.Progress in retinal and eye research · 2021Review
- Adaptive optics: principles and applications in ophthalmology.Eye (London, England) · 2021Review
- Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography.Journal of visualized experiments : JoVE · 2020Article
- Article
- Hypercapnia Impairs Vasoreactivity to Changes in Blood Pressure and Intraocular Pressure in Rat Retina.Optometry and vision science : official publication of the American Academy of Optometry · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although changes in vessel diameter following gas perturbation have been documented in retinal arterioles and venules, these responses have yet to be quantified in the smallest vessels of the human retina. Here, using in vivo adaptive optics, we imaged 3-25 µm diameter vessels of the human inner retinal circulation and monitored the effects of altered gas-breathing conditions. During isocapnic hyperoxia, definite constrictions were seen in 51% of vessel segments (mean ± SD for pre-capillary arterioles -9.5 ± 3.0%; capillaries -11.8 ± 3.3%; post-capillary venules -6.3 ± 2.8%); these are comparable with responses previously reported in larger vessels. During isoxic hypercapnia, definite dilations were seen in 47% of vessel segments (mean ± SD for pre-capillary arterioles +9.8 ± 1.5%; capillaries +13.7 ± 3.8%; post-capillary venules +7.5 ± 4.2%); these are proportionally greater than responses previously reported in larger vessels. The magnitude of these proportional changes implies that the capillary beds themselves play an important role in the retinal response to changes in carbon dioxide levels. Interestingly, the distribution of microvascular responses shown here differs from our previously reported responses to flicker stimulation, suggesting differences in the way blood supply is coordinated following gas perturbation and altered neural activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.