Evidence map›Paper›PMID 28522690›Full record

ArticleScience (New York, N.Y.)2017

Resistance to malaria through structural variation of red blood cell invasion receptors.

Ellen M Leffler, Gavin Band, George B J Busby, Katja Kivinen, Quang Si Le, Geraldine M Clarke, Kalifa A Bojang, David J Conway, Muminatou Jallow, Fatoumatta Sisay-Joof and 31 more

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
23.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 193 citations in OpenAlex.

  1. Trial
  2. Article
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  4. Article
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  9. Article
  10. Article
  11. Human genetic variations conferring resistance to malaria.Journal of translational medicine · 2025
    Review
  12. Article
  13. Mendelian Randomization and Infection: Pitfalls and Promises.The Journal of infectious diseases · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Blood group antigens and malaria susceptibility.Frontiers in cellular and infection microbiology · 2025
    Review
  19. Article
  20. Fitness consequences of structural variation inferred from a House Finch pangenome.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

41 authors at 12 institutions in 10 countries.

Ellen M LefflerWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.ORCID 0000-0002-1614-9366
Gavin BandWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.ORCID 0000-0002-1710-9024
George B J BusbyWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.ORCID 0000-0003-4148-6222
Katja KivinenWellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Quang Si LeWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Geraldine M ClarkeWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.ORCID 0000-0001-7249-0289
Kalifa A BojangMedical Research Council Unit, Atlantic Boulevard, Fajara, Post Office Box 273, The Gambia.ORCID 0000-0001-7506-0938
David J ConwayMedical Research Council Unit, Atlantic Boulevard, Fajara, Post Office Box 273, The Gambia.ORCID 0000-0002-8711-3037
Muminatou JallowMedical Research Council Unit, Atlantic Boulevard, Fajara, Post Office Box 273, The Gambia.
Fatoumatta Sisay-JoofMedical Research Council Unit, Atlantic Boulevard, Fajara, Post Office Box 273, The Gambia.
Edith C BougoumaCentre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 2208 Ouagadougou 01, Burkina Faso.
Valentina D ManganoUniversity of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy.
David ModianoUniversity of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Sodiomon B SirimaCentre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 2208 Ouagadougou 01, Burkina Faso.
Eric AchidiDepartment of Medical Laboratory Sciences, University of Buea, Post Office Box 63, Buea, South West Region, Cameroon.
Tobias O ApinjohDepartment of Biochemistry and Molecular Biology, University of Buea, Post Office Box 63, Buea, South West Region, Cameroon.
Kevin MarshKenyan Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Post Office Box 230-80108, Kilifi, Kenya.ORCID 0000-0001-8377-5466
Carolyne M NdilaKenyan Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Post Office Box 230-80108, Kilifi, Kenya.ORCID 0000-0002-5694-3652
Norbert PeshuKenyan Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Post Office Box 230-80108, Kilifi, Kenya.
Thomas N WilliamsKenyan Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Post Office Box 230-80108, Kilifi, Kenya.ORCID 0000-0003-4456-2382
Chris DrakeleyJoint Malaria Programme, Kilimanjaro Christian Medical Centre, Post Office Box 2228, Moshi, Tanzania.
Alphaxard ManjuranoJoint Malaria Programme, Kilimanjaro Christian Medical Centre, Post Office Box 2228, Moshi, Tanzania.
Hugh ReyburnJoint Malaria Programme, Kilimanjaro Christian Medical Centre, Post Office Box 2228, Moshi, Tanzania.
Eleanor RileyFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
David KachalaMalawi-Liverpool-Wellcome Trust Clinical Research Programme, Queen Elizabeth Central Hospital, College of Medicine, Post Office Box 30096, Chichiri, Blantyre 3, Malawi.
Malcolm MolyneuxMalawi-Liverpool-Wellcome Trust Clinical Research Programme, Queen Elizabeth Central Hospital, College of Medicine, Post Office Box 30096, Chichiri, Blantyre 3, Malawi.
Vysaul NyirongoMalawi-Liverpool-Wellcome Trust Clinical Research Programme, Queen Elizabeth Central Hospital, College of Medicine, Post Office Box 30096, Chichiri, Blantyre 3, Malawi.
Terrie TaylorBlantyre Malaria Project, Queen Elizabeth Central Hospital, College of Medicine, Post Office Box 30096, Chichiri, Blantyre 3, Malawi.ORCID 0000-0001-7416-3986
Nicole ThorntonInternational Blood Group Reference Laboratory, National Health Service (NHS) Blood and Transplant, 500 North Bristol Park, Filton, Bristol BS34 7QH, UK.ORCID 0000-0002-8635-0997
Louise TilleyInternational Blood Group Reference Laboratory, National Health Service (NHS) Blood and Transplant, 500 North Bristol Park, Filton, Bristol BS34 7QH, UK.
Shane GrimsleyInternational Blood Group Reference Laboratory, National Health Service (NHS) Blood and Transplant, 500 North Bristol Park, Filton, Bristol BS34 7QH, UK.
Eleanor DruryWellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0002-9887-6961
Jim StalkerWellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0001-7076-8988
Victoria CorneliusWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Christina HubbartWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.ORCID 0000-0001-9576-9581
Anna E JeffreysWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.ORCID 0000-0002-6454-3093
Kate RowlandsWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.ORCID 0000-0002-3519-0612
Kirk A RockettWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.ORCID 0000-0002-6369-9299
Chris C A SpencerWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. chris.spencer@well.ox.ac.uk dominic.kwiatkowski@sanger.ac.uk.ORCID 0000-0002-8508-456X
Dominic P KwiatkowskiWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. chris.spencer@well.ox.ac.uk dominic.kwiatkowski@sanger.ac.uk.ORCID 0000-0002-5023-0176
Malaria Genomic Epidemiology Network
Centre for Human Genetics · GBUniversity of London · GBKenya Medical Research Institute · KENHS Blood and Transplant · GBUniversity of Liverpool · GBWellcome Sanger Institute · GBCentre National de Recherche et de Formation sur le Paludisme · BFMRC Unit the Gambia · GMSapienza University of Rome · ITUniversity of Buea · CMEdward Francis Small Teaching Hospital · GMQueen Elizabeth Central Hospital · MW

Funding

Medical Research Council G0600230Medical Research Council G0600718Medical Research Council MC_UP_A900_1118Medical Research Council MR/M006212/1Wellcome Trust 084538Wellcome Trust 098051Wellcome Trust 204911/Z/16/Z
6 · The paper itself

Abstract

The malaria parasite

Indexed as

GlycophorinsModels, MolecularAdultAfrica South of the SaharaChildDisease ResistanceDNA Copy Number VariationsErythrocytesGene FrequencyGenome, HumanHost-Parasite InteractionsHumansMalaria, FalciparumProtein Structure, SecondaryReceptors, Cell Surfaceglycophorin DantuGlycophorinsGYPA protein, humanGYPB protein, humanReceptors, Cell Surface

Identifiers

PMID28522690
PMCPMC5575826
OpenAlexW2616090912

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.