ArticleJournal of the American Heart Association2017
Midlife and Late-Life Vascular Risk Factors and White Matter Microstructural Integrity: The Atherosclerosis Risk in Communities Neurocognitive Study.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Utilisation of brain MRI for the diagnosis of dementia in low and middle-income countries: systematic review and meta-analysis.BMJ open · 2026Pooled it
- Relationship Between Type 2 Diabetes and White Matter Hyperintensity: A Systematic Review.Frontiers in endocrinology · 2020Pooled it
- Reduced structural connectivity in age-related hearing loss aligns with the sensory deprivation theory.GeroScience · 2026Article
- Association between vascular risk factors and white matter integrity among diverse predominantly older Hispanic/Latino adults from the SOL-INCA MRI study.GeroScience · 2026Article
- Association between cardiovascular disease risk factors and white matter lesions: The Tohoku Medical Megabank Cohort Study.Journal of atherosclerosis and thrombosis · 2026Article
- Association between neuroticism and brain-wide structural outcomes: Mediation by vascular and mental conditions.Psychological medicine · 2025Article
- Article
- Midlife Retinal Microvascular Signs and Late-Life Neuroimaging Features of Cerebral Small Vessel Disease in the ARIC Study.Neurology · 2025Article
- Blood pressure and the brain: the conundrum of hypertension and dementia.Cardiovascular research · 2025Review
- Correlation between blood pressure control status and cognitive impairment in older adults: A national cross-sectional study.PloS one · 2025Article
- Association of Blood Pressure With Brain White Matter Microstructural Integrity Assessed With MRI Diffusion Tensor Imaging in Healthy Young Adults.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Structural white matter properties and cognitive resilience to tau pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Effect of the duration of hypertension on white matter structure and its link with cognition.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Atherosclerosis and Hippocampal Volumes in Older Adults: The Role of Age and Blood Pressure.Journal of the American Heart Association · 2024Article
- Mid-Life Vascular Risk and Rate of Physical Function Decline Among Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Hypertension Trends and White Matter Brain Injury in the Offspring Framingham Heart Study Cohort.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Serum Proteomic Signatures of Common Health Outcomes among Older Adults.Gerontology · 2024Article
- Article
- Regional Vulnerability of the Corpus Callosum in the Context of Cardiovascular Risk.Journal of geriatric psychiatry and neurology · 2023Article
- The need to change: Is there a critical role of midlife adaptation in mental health later in life?eLife · 2023Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundDiffusion tensor imaging measures of white matter (WM) microstructural integrity appear to provide earlier indication of WM injury than WM hyperintensities; however, risk factors for poor WM microstructural integrity have not been established. Our study quantifies the association between vascular risk factors in midlife and late life with measures of late-life WM microstructural integrity. METHODS AND
resultsWe used data from 1851 participants in ARIC (Atherosclerosis Risk in Communities Study) who completed 3-T magnetic resonance imaging, including diffusion tensor imaging, as part of the ARIC Neurocognitive Study (ARIC-NCS). We quantified the association among lipids, glucose, and blood pressure from the baseline ARIC visit (1987-1989, ages 44-65, midlife) and visit 5 of ARIC (2011-2013, ages 67-90, late life, concurrent with ARIC-NCS) with regional and overall WM mean diffusivity and fractional anisotropy obtained at ARIC visit 5 for ARIC participants. We also considered whether these associations were independent of or modified by WM hyperintensity volumes. We found that elevated blood pressure in midlife and late life and elevated glucose in midlife, but not late life, were associated with worse late-life WM microstructural integrity. These associations were independent of the degree of WM hyperintensity, and the association between glucose and WM microstructural integrity appeared stronger for those with the least WM hyperintensity. There was little support for an adverse association between lipids and WM microstructural integrity.
conclusionsHypertension in both midlife and late life and elevated glucose in midlife are related to worse WM microstructural integrity in late life.
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