Evidence map›Paper›PMID 28522607›Full record

ArticleThe Journal of biological chemistry2017

NleB/SseK effectors from

Samir El Qaidi, Kangming Chen, Adnan Halim, Lina Siukstaite, Christian Rueter, Ramon Hurtado-Guerrero, Henrik Clausen, Philip R Hardwidge

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Mechanism of Bacterial ArginineACS catalysis · 2026
    Article
  3. Adaptive Evolution ofMicroorganisms · 2025
    Article
  4. Article
  5. Article
  6. Speaking the host language: howMicrobiology (Reading, England) · 2023
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Glycosylating Effectors ofBiomolecules · 2022
    Review
  12. Applied and environmental microbiology · 2022
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Global view of human protein glycosylation pathways and functions.Nature reviews. Molecular cell biology · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Samir El QaidiFrom the College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506.
Kangming ChenFrom the College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506.
Adnan Halimthe Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
Lina Siukstaitethe Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
Christian Rueterthe Institute of Infectiology, Center for Molecular Biology of Inflammation, University of Muenster, 48149 Muenster, Germany, and.
Ramon Hurtado-Guerrerothe Fundacion ARAID, Edificio CEEI ARAGÓN and Institute of Biocomputation and Physics of Complex Systems, University of Zaragoza, Instituto de Quimica Fisica Rocasolano, Consejo Superior de Investigaciones Científicas Joint Unit, 500018 Zaragoza, Spain.
Henrik Clausenthe Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
Philip R HardwidgeFrom the College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, hardwidg@vet.k-state.edu.
Kansas State University · USUniversity of Copenhagen · DKInstitute of Molecular Biology · DEUniversidad de Zaragoza · ES

Funding

Bacterial effectors targeting the IKK/NF-kB pathwayR01AI099002 · NIAID · KANSAS STATE UNIVERSITY · PI HARDWIDGE, PHILIP ROSS · 2013 to 2017
$1.6M
Functions of Translocated Bacterial GlycosyltransferasesR21AI127973 · NIAID · KANSAS STATE UNIVERSITY · PI HARDWIDGE, PHILIP ROSS · 2017 to 2018
$413k
Bacterial effector inhibition of type I interferonR21AI093913 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI HARDWIDGE, PHILIP ROSS · 2011 to 2012
$375k
NIAID NIH HHS R01 AI099002NIAID NIH HHS R21 AI093913NIAID NIH HHS R21 AI127973
6 · The paper itself

Abstract

Many Gram-negative bacterial pathogens use a syringe-like apparatus called a type III secretion system to inject virulence factors into host cells. Some of these effectors are enzymes that modify host proteins to subvert their normal functions. NleB is a glycosyltransferase that modifies host proteins with

Indexed as

AnimalsBacterial ProteinsCitrobacter rodentiumEnterohemorrhagic Escherichia coliEnteropathogenic Escherichia coliEscherichia coli ProteinsFas-Associated Death Domain ProteinGlyceraldehyde-3-Phosphate DehydrogenasesGlycosylationMiceRAW 264.7 CellsReceptors, Tumor Necrosis Factor, Type IISalmonella entericaTNF Receptor-Associated Factor 2UbiquitinationVirulence FactorsBacterial ProteinsEscherichia coli ProteinsFadd protein, mouseFas-Associated Death Domain ProteinGlyceraldehyde-3-Phosphate DehydrogenasesNleB protein, E coliReceptors, Tumor Necrosis Factor, Type IISseK1 protein, Salmonella entericaSseK2 protein, Salmonella entericaTNF Receptor-Associated Factor 2Virulence Factorsbacterial pathogenesisglycosyltransferaseinnate immunitysignal transductionvirulence factor

Identifiers

PMID28522607
PMCPMC5500807
OpenAlexW2616359747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.