ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017
SMAD4 Loss Is Associated with Cetuximab Resistance and Induction of MAPK/JNK Activation in Head and Neck Cancer Cells.
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Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 75 citations in OpenAlex.
- SMAD4 Expression and Its Association With Treatment Resistance and Clinical Outcomes in Oral Squamous Cell Carcinoma Treated With Preoperative Chemoradiotherapy.Cancer reports (Hoboken, N.J.) · 2026Article
- Drug-tolerant persister cells in head and neck squamous cell carcinoma: Molecular mechanisms and therapeutic opportunities.Translational oncology · 2026Article
- Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy.Cell reports. Medicine · 2024Article
- Suppressive cancer nonstop extension mutations increase C-terminal hydrophobicity and disrupt evolutionarily conserved amino acid patterns.Nature communications · 2024Article
- Unveiling the role of RAC3 in the growth and invasion of cisplatin-resistant bladder cancer cells.Journal of cellular and molecular medicine · 2024Article
- A Tissue Engineered 3D Model of Cancer Cell Invasion for Human Head and Neck Squamous-Cell Carcinoma.Current issues in molecular biology · 2024Article
- LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4.Biology direct · 2024Article
- Protein disulfide isomerase family member 4 promotes triple-negative breast cancer tumorigenesis and radiotherapy resistance through JNK pathway.Breast cancer research : BCR · 2024Article
- The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma.Journal of inflammation research · 2023Review
- The effect of SMAD4 on the prognosis and immune response in hypopharyngeal carcinoma.Frontiers in medicine · 2023Article
- Article
- Long non-coding RNA SNHG16 decreased SMAD4 to induce gemcitabine resistance in pancreatic cancer via EZH2-mediated epigenetic modification.The Kaohsiung journal of medical sciences · 2022Article
- MAPK Signaling Pathway in Oral Squamous Cell Carcinoma: Biological Function and Targeted Therapy.Cancers · 2022Review
- An EGFR/HER2-targeted conjugate sensitizes gemcitabine-sensitive and resistant pancreatic cancer through different SMAD4-mediated mechanisms.Nature communications · 2022Article
- Transcriptome‑based drug repositioning identifies TPCA‑1 as a potential selective inhibitor of esophagus squamous carcinoma cell viability.International journal of molecular medicine · 2022Article
- Analysis of the epidermal growth factor receptor/phosphoinositide-dependent protein kinase-1 axis in tumor of the external auditory canal in response to epidermal growth factor stimulation.Laryngoscope investigative otolaryngology · 2022Article
- Integrative analysis of TCGA data identifies miRNAs as drug-specific survival biomarkers.Scientific reports · 2022Article
- Single Circulating-Tumor-Cell-Targeted Sequencing to Identify Somatic Variants in Liquid Biopsies in Non-Small-Cell Lung Cancer Patients.Current issues in molecular biology · 2022Article
- Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer.Molecular cancer · 2022Review
- Multiple roles of mothers against decapentaplegic homolog 4 in tumorigenesis, stem cells, drug resistance, and cancer therapy.World journal of stem cells · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 3 institutions in 1 country.
Hiroyuki OzawaDepartment of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
Ruchira S RanaweeraDepartment of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
Evgeny IzumchenkoDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Eugene MakarevInsilico Medicine, Inc, ETC, Johns Hopkins University, Baltimore, Maryland.
Alex ZhavoronkovInsilico Medicine, Inc, ETC, Johns Hopkins University, Baltimore, Maryland.
Elana J FertigDepartment of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
Jason D HowardDepartment of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
Ana MarkovicDepartment of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
Atul BediDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Rajani RaviDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jimena PerezDepartment of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
Quynh-Thu LeDepartment of Pathology, Stanford University School of Medicine Stanford, California.
Christina S KongDepartment of Pathology, Stanford University School of Medicine Stanford, California.
Richard C JordanDepartments of Orofacial Sciences and Pathology, University of California, San Francisco, San Francisco, CA, USA.
Hao WangDepartment of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
Hyunseok KangDepartment of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
Harry QuonDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland.
David SidranskyDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Christine H ChungDepartment of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland. Christine.Chung@Moffitt.Org.
Johns Hopkins University · USStanford Medicine · USUniversity of California, San Francisco · US
Funding
TUMOR SUPPRESOR GENE PROMOTER HYPERMETHYLATION FOR DETECTION OF HEAD AND NECKP50DE019032 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI WESTRA, WILLIAM H · 2007 to 2016
$27.1MMolecular signatures of HNSCC in response to targeted therapiesR01DE017982 · NIDCR · VANDERBILT UNIVERSITY · PI CHUNG, CHRISTINE H · 2007 to 2011
$1.9MDynamical Models of Cetuximab Resistance in HNSCC Based on Serial Genomics DataR01CA177669 · NCI · JOHNS HOPKINS UNIVERSITY · PI FERTIG, ELANA · 2014 to 2019
$1.8MSmad4-independent TGF-b signaling in p16-negative HNSCCR21DE023430 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI CHUNG, CHRISTINE H · 2014 to 2015
$452kIdentifying Malignant Cell Signaling from Protein Interactions an Polyomic DataK25CA141053 · NCI · JOHNS HOPKINS UNIVERSITY · PI FERTIG, ELANA · 2010 to 2014
$419kNCI NIH HHS K25 CA141053NCI NIH HHS R01 CA177669NIDCR NIH HHS P50 DE019032NIDCR NIH HHS R01 DE017982NIDCR NIH HHS R21 DE023430
Abstract
PubMed holds no abstract for this paper.
Indexed as
AgedAnimalsAntibodies, Monoclonal, HumanizedCell Line, TumorCetuximabDrug Resistance, NeoplasmErbB ReceptorsFemaleGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHumansMAP Kinase Kinase 1MiceMiddle AgedNeoplasm Recurrence, LocalPapillomaviridaeAntibodies, Monoclonal, HumanizedCetuximabEGFR protein, humanErbB ReceptorsMAP Kinase Kinase 1Protein Kinase InhibitorsSmad4 ProteinSMAD4 protein, human
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