Evidence map›Paper›PMID 28522563›Full record

ReviewAmerican journal of physiology. Lung cellular and molecular physiology2017

Biomarkers of exposure to new and emerging tobacco delivery products.

Suzaynn F Schick, Benjamin C Blount, Peyton Jacob, Najat A Saliba, John T Bernert, Ahmad El Hellani, Peter Jatlow, R Steven Pappas, Lanqing Wang, Jonathan Foulds and 14 more

Open access · greenAbstract readReview
In one paragraph

Review in American journal of physiology. Lung cellular and molecular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 2 syntheses or guidelines pooled it, 140 citations in OpenAlex.

  1. Pulmonary effects of e-liquid flavors: a systematic review.Journal of toxicology and environmental health. Part B, Critical reviews · 2022
    Pooled it
  2. Guideline
  3. Trial
  4. Biomarkers of Tobacco Exposure Decrease After Smokers Switch to an E-Cigarette or Nicotine Gum.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019
    Trial
  5. Comparing brain absorption and lung deposition of nicotine salts and free-base e-cigarettes: insights from [Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Differential metabolic profiles by training fire exposure in female firefighters.International journal of hygiene and environmental health · 2026
    Article
  10. Gestational diabetes and childhood lung function at age 8 to 9 years in a diverse US cohort.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026
    Article
  11. Article
  12. Article
  13. Biomarkers of Exposure to Tobacco-Related Toxicants among Adult Nicotine Pouch Users.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. High-throughput UPLC-ESI/MSMS method for simultaneous measurement of the urinary metabolites of volatile organic compounds and tobacco alkaloids.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2025
    Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 13 institutions in 2 countries.

Suzaynn F SchickDivision of Occupational and Environmental Medicine, Department of Medicine, University of California, San Francisco, California; suzaynn.schick@ucsf.edu.
Benjamin C BlountCenters for Disease Control and Prevention, Atlanta, Georgia.
Peyton JacobDivision of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California, San Francisco, California.
Najat A SalibaDepartment of Chemistry, American University of Beirut, Beirut, Lebanon.
John T BernertCenters for Disease Control and Prevention, Atlanta, Georgia.
Ahmad El HellaniDepartment of Chemistry, American University of Beirut, Beirut, Lebanon.
Peter JatlowDepartments of Laboratory Medicine and Psychiatry, Yale University, New Haven, Connecticut.
R Steven PappasCenters for Disease Control and Prevention, Atlanta, Georgia.
Lanqing WangCenters for Disease Control and Prevention, Atlanta, Georgia.
Jonathan FouldsTobacco Center of Regulatory Science, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania.
Arunava GhoshMarsico Lung Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Stephen S HechtMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
John C GomezMarsico Lung Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Jessica R MartinMarsico Lung Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Clementina MesarosDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania.
Sanjay SrivastavaDepartment of Medicine, Institute of Molecular Cardiology and Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky.
Gideon St HelenDivision of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California, San Francisco, California.
Robert TarranMarsico Lung Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Pawel K LorkiewiczDepartment of Medicine, Institute of Molecular Cardiology and Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky.
Ian A BlairDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania.
Heather L KimmelDivision of Epidemiology, Services and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland.
Claire M DoerschukMarsico Lung Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Neal L BenowitzDivision of Clinical Pharmacology and Experimental Therapeutics, Departments of Medicine and Bioengineering and Therapeutic Sciences, University of California, San Francisco, California; and.
Aruni BhatnagarDepartment of Medicine, Institute of Molecular Cardiology and Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky.
Centers for Disease Control and Prevention · USUniversity of California, San Francisco · USUniversity of North Carolina at Chapel Hill · USAmerican University of Beirut · LBLung Institute · USUniversity of Louisville · USAmerican Heart Association · USNational Institute on Drug Abuse · USPennsylvania State University · USTranslational Therapeutics (United States) · USUniversity of Minnesota Medical Center · USUniversity of Pennsylvania · USYale University · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3M
Yale Tobacco Center of Regulatory ScienceP50DA036151 · NIDA · YALE UNIVERSITY · PI KRISHNAN-SARIN, SUCHITRA, O'MALLEY, STEPHANIE S · 2013 to 2017
$20.6M
Training and Education p489-500P50CA180890 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLANTZ, STANTON ARNOLD · 2013 to 2018
$20.5M
Research Training and Education Core (Core D) P50HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2013 to 2017
$20.1M
Research Training and Educational Component (Component I) p370-385P50DA036107 · NIDA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI FOULDS, JONATHAN, MUSCAT, JOSHUA E · 2013 to 2018
$19.5M
Tobacco Products and Atherosclerotic DiseaseR01HL120746 · NHLBI · UNIVERSITY OF LOUISVILLE · PI SRIVASTAVA, SANJAY · 2013 to 2017
$3.7M
NCI NIH HHS P30 CA016520NCI NIH HHS P50 CA180890NHLBI NIH HHS P50 HL120163NHLBI NIH HHS R01 HL120746NIDA NIH HHS P50 DA036107NIDA NIH HHS P50 DA036151
6 · The paper itself

Abstract

Accurate and reliable measurements of exposure to tobacco products are essential for identifying and confirming patterns of tobacco product use and for assessing their potential biological effects in both human populations and experimental systems. Due to the introduction of new tobacco-derived products and the development of novel ways to modify and use conventional tobacco products, precise and specific assessments of exposure to tobacco are now more important than ever. Biomarkers that were developed and validated to measure exposure to cigarettes are being evaluated to assess their use for measuring exposure to these new products. Here, we review current methods for measuring exposure to new and emerging tobacco products, such as electronic cigarettes, little cigars, water pipes, and cigarillos. Rigorously validated biomarkers specific to these new products have not yet been identified. Here, we discuss the strengths and limitations of current approaches, including whether they provide reliable exposure estimates for new and emerging products. We provide specific guidance for choosing practical and economical biomarkers for different study designs and experimental conditions. Our goal is to help both new and experienced investigators measure exposure to tobacco products accurately and avoid common experimental errors. With the identification of the capacity gaps in biomarker research on new and emerging tobacco products, we hope to provide researchers, policymakers, and funding agencies with a clear action plan for conducting and promoting research on the patterns of use and health effects of these products.

Indexed as

Electronic Nicotine Delivery SystemsBiomarkersEnvironmental ExposureHumansMetabolomeNicotianaNicotineBiomarkersNicotinebiomarkercotinineexposureNNALtobacco

Identifiers

PMID28522563
PMCPMC5626373
OpenAlexW2614141206

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.