Evidence map›Paper›PMID 28522536›Full record

ArticleScience (New York, N.Y.)2017

A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568.

Peng Yang, Yixuan Wang, Don Hoang, Matthew Tinkham, Anamika Patel, Ming-An Sun, Gernot Wolf, Mairead Baker, Huan-Chieh Chien, Kuan-Yu Nick Lai and 3 more

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 69 citations in OpenAlex.

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  19. Transcription Factor Dynamics.Cold Spring Harbor perspectives in biology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Peng YangThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-9724-7936
Yixuan WangThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Don HoangThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-6651-4309
Matthew TinkhamThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-9765-8567
Anamika PatelDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0003-4760-9019
Ming-An SunThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-4661-3027
Gernot WolfThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-3943-8662
Mairead BakerThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Huan-Chieh ChienDepartment of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan, Republic of China.ORCID 0000-0002-0499-2145
Kuan-Yu Nick LaiDepartment of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan, Republic of China.ORCID 0000-0001-8451-0953
Xiaodong ChengDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.
Che-Kun James ShenDepartment of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan, Republic of China. todd.macfarlan@nih.gov ckshen@gate.sinica.edu.tw.ORCID 0000-0001-6515-5837
Todd S MacfarlanThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. todd.macfarlan@nih.gov ckshen@gate.sinica.edu.tw.ORCID 0000-0003-2495-9809
National Institutes of Health · USNational Yang Ming Chiao Tung University · TWEmory University · US

Funding

Mechanisms of Mammalian Epigenome ReprogrammingZIAHD008933 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MACFARLAN, TODD SCOTT · 2013 to 2025
$19.1M
THREE-DIMENSIONAL STRUCTURE OF HHAI METHYLASER01GM049245 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHENG, XIAODONG · 1993 to 2017
$6.6M
Intramural NIH HHS ZIA HD008933NICHD NIH HHS ZIA HD008933NIGMS NIH HHS R01 GM049245
6 · The paper itself

Abstract

Insulin-like growth factor 2 (IGF2) is the major fetal growth hormone in mammals. We identify zinc finger protein 568 (ZFP568), a member of the rapidly evolving Kruppel-associated box-zinc finger protein (KRAB-ZFP) family linked primarily to silencing of endogenous retroelements, as a direct repressor of a placental-specific

Indexed as

AnimalsEmbryo, MammalianFemaleGastrulationGene Expression RegulationInsulin-Like Growth Factor IIMiceMice, KnockoutMutationNuclear ProteinsPlacentaPregnancyPromoter Regions, GeneticRepressor ProteinsIGF2 protein, mouseInsulin-Like Growth Factor IINuclear ProteinsRepressor ProteinsZfp568 protein, mouse

Identifiers

PMID28522536
PMCPMC6309218
OpenAlexW2614741472

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.