Evidence map›Paper›PMID 28522011›Full record

ArticleVaccine2017

Vaccination with a live attenuated Acinetobacter baumannii deficient in thioredoxin provides protection against systemic Acinetobacter infection.

Sarah Ainsworth, Patrick M Ketter, Jieh-Juen Yu, Rose C Grimm, Holly C May, Andrew P Cap, James P Chambers, M Neal Guentzel, Bernard P Arulanandam

Abstract read
In one paragraph

Article in Vaccine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Epidemiology ofFrontiers in public health · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Non-antibiotic prevention and treatment againstFrontiers in microbiology · 2023
    Review
  10. Article
  11. Insights intoFrontiers in immunology · 2022
    Review
  12. Review
  13. Sequential Vaccination With HeterologousFrontiers in immunology · 2021
    Article
  14. Recent Advances in the Pursuit of an EffectivePathogens (Basel, Switzerland) · 2020
    Review
  15. Emerging Strategies to Combat β-Lactamase Producing ESKAPE Pathogens.International journal of molecular sciences · 2020
    Review
  16. Antimicrobial Resistance in ESKAPE Pathogens.Clinical microbiology reviews · 2020
    Review
  17. The Mechanisms of Disease Caused byFrontiers in microbiology · 2019
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sarah AinsworthSouth Texas Center for Emerging Infectious Disease and the Center for Excellence in Infection Genomics, University of Texas at San Antonio; San Antonio, TX 78249, United States.
Patrick M KetterCoagulation and Blood Research Program, US Army Institute for Surgical Research, JBSA Fort Sam Houston, TX 78234, United States.
Jieh-Juen YuSouth Texas Center for Emerging Infectious Disease and the Center for Excellence in Infection Genomics, University of Texas at San Antonio; San Antonio, TX 78249, United States.
Rose C GrimmComparative Pathology Division, US Army Institute for Surgical Research, JBSA Fort Sam Houston, TX 78234, United States.
Holly C MaySouth Texas Center for Emerging Infectious Disease and the Center for Excellence in Infection Genomics, University of Texas at San Antonio; San Antonio, TX 78249, United States.
Andrew P CapCoagulation and Blood Research Program, US Army Institute for Surgical Research, JBSA Fort Sam Houston, TX 78234, United States.
James P ChambersSouth Texas Center for Emerging Infectious Disease and the Center for Excellence in Infection Genomics, University of Texas at San Antonio; San Antonio, TX 78249, United States.
M Neal GuentzelSouth Texas Center for Emerging Infectious Disease and the Center for Excellence in Infection Genomics, University of Texas at San Antonio; San Antonio, TX 78249, United States.
Bernard P ArulanandamSouth Texas Center for Emerging Infectious Disease and the Center for Excellence in Infection Genomics, University of Texas at San Antonio; San Antonio, TX 78249, United States. Electronic address: bernard.arulanandam@utsa.edu.
Texas Center for Infectious Disease · USUnited States Army Institute of Surgical Research · US

Funding

Thioredoxin mediated Acinetobacter baumannii colonization in the GI tractR21AI124021 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI ARULANANDAM, BERNARD PRAGASH · 2016 to 2017
$404k
NIAID NIH HHS R21 AI124021
6 · The paper itself

Abstract

Multi-drug resistant Acinetobacter baumannii (MDR-Ab), an opportunistic pathogen associated with nosocomial and combat related infections, has a high mortality due to its virulence and limited treatment options. Deletion of the thioredoxin gene (TrxA) from a clinical isolate of MDR-Ab resulted in a 100-fold increase in 50% lethal dose (LD

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAnimalsAntibodies, BacterialBacterial LoadBacterial VaccinesC-Reactive ProteinCytokinesGene DeletionImmunity, MucosalImmunization, PassiveImmunoglobulin Class SwitchingImmunoglobulin MMiceMice, Inbred C57BLPentraxinsAntibodies, BacterialBacterial VaccinesC-Reactive ProteinCytokinesImmunoglobulin MPentraxinsSerum Amyloid P-ComponentThioredoxinsVaccines, AttenuatedVirulence FactorsAcinetobacter baumanniiPentraxin-3ThioredoxinVaccine

Identifiers

PMID28522011
PMCPMC5510955
OpenAlexW2615808187

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.