SynthesisInternational journal of oral and maxillofacial surgery2017
Does local delivery of bisphosphonates influence the osseointegration of titanium implants? A systematic review.
Synthesis in International journal of oral and maxillofacial surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Effect of bisphosphonate treatment of titanium surfaces on alkaline phosphatase activity in osteoblasts: a systematic review and meta-analysis.BMC oral health · 2020Pooled it
- Bone density changes after five or more years of unilateral lower extremity osseointegration: Observational cohort study.Bone reports · 2023Article
- The relative contribution of bone microarchitecture and matrix composition to implant fixation strength in rats.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Bisphosphonate-based surface biofunctionalization improves titanium biocompatibility.Journal of materials science. Materials in medicine · 2020Article
- Biofunctionalization of titanium surfaces with alendronate and albumin modulates osteoblast performance.Heliyon · 2020Article
- The influence of local delivery of bisphosphonate on osseointegration of dental implants.Evidence-based dentistry · 2018Article
- Simple 3,4-Dihydroxy-L-Phenylalanine Surface Modification Enhances Titanium Implant Osseointegration in Ovariectomized Rats.Scientific reports · 2017Article
- Dental Implant Placement in Patients on Bisphosphonate Therapy: a Systematic Review.Journal of oral & maxillofacial researchReview
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to systematically review the influence of the local delivery of bisphosphonates on the osseointegration of titanium implants in humans. A search of health sciences databases was performed (The Cochrane Library, Embase, PubMed MEDLINE, ISI Web of Knowledge, Scopus, and SIGLE OpenGrey), including articles published until October 2016. A total of 679 articles were identified. Following the removal of duplicates, 278 were screened by title and abstract. The complete texts of seven studies were read, and of these, three met the inclusion criteria. Each article included in the analysis was submitted to a quality and level of evidence evaluation, and relevant data were extracted and tabulated. Despite methodological differences, all articles presented positive results for osseointegration when a local bisphosphonate was used: the authors reported greater implant stability, better implant survival rates, and reduced peri-implant bone loss when compared with the control groups. On the basis of the results of this systematic review, it is concluded that the local use of a bisphosphonate appears to favour the osseointegration of titanium implants in humans. Nonetheless, a higher level of standardization and the control of methodological bias is required in future research so that stronger evidence might be produced.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.