Evidence map›Paper›PMID 28521937›Full record

ReviewCurrent opinion in insect science2017

Using Drosophila pigmentation traits to study the mechanisms of cis-regulatory evolution.

Mark Rebeiz, Thomas M Williams

Abstract readReview
In one paragraph

Review in Current opinion in insect science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

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  15. AInternational journal of molecular sciences · 2021
    Article
  16. Review
  17. Article
  18. Article
  19. Frontiers in ecology and evolution · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mark RebeizDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address: rebeiz@pitt.edu.
Thomas M WilliamsDepartment of Biology, University of Dayton, 300 College Park, Dayton, OH 45469, USA. Electronic address: twilliams2@udayton.edu.

Funding

Dissecting the molecular basis and assembly of a complex morphological traitR01GM114093 · NIGMS · PRINCETON UNIVERSITY · PI ANDOLFATTO, PETER, REBEIZ, MARK J · 2015 to 2018
$1.8M
NIGMS NIH HHS R01 GM114093
6 · The paper itself

Abstract

One primary agenda of the developmental evolution field is to elucidate molecular mechanisms governing differences in animal form. While mounting evidence has established an important role for mutations in transcription controlling cis-regulatory elements (CREs), the underlying mechanisms that translate these alterations into differences in gene expression are poorly understood. Emerging studies focused on pigmentation differences among closely related Drosophila species have provided many examples of phenotypically relevant CRE changes, and have begun to illuminate how this process works at the level of regulatory sequence function and transcription factor binding. We review recent work in this field and highlight the conceptual and technical challenges that currently await experimental attention.

Indexed as

Biological EvolutionGene Expression Regulation, DevelopmentalGene Regulatory NetworksAnimalsDrosophilaPigmentation

Identifiers

PMID28521937
PMCPMC5439306

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.