ArticleBMC musculoskeletal disorders2017
Incidence of total hip or knee replacement due to osteoarthritis in relation to thyroid function: a prospective cohort study (The Nord-Trøndelag Health Study).
Article in BMC musculoskeletal disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Hypothyroidism is associated with higher healthcare utilisation and higher need for blood transfusion after primary total knee arthroplasty (TKA) in patients with osteoarthritis: A National Inpatient Sample analysis.Journal of experimental orthopaedics · 2026Article
- Genetic evidence links hyperthyroidism to knee osteoarthritis.Hormones (Athens, Greece) · 2025Article
- Association of thyroid hormone with osteoarthritis: from mendelian randomization and RNA sequencing analysis.Journal of orthopaedic surgery and research · 2024Article
- Hyperthyroidism increases the risk of osteoarthritis in individuals aged 60-80 years.Scientific reports · 2024Article
- Causal relationship between modifiable risk factors and knee osteoarthritis: a Mendelian randomization study.Frontiers in medicine · 2024Article
- Effect of Hypothyroidism on Complications in Patients Undergoing TKA in Indian Population.Indian journal of orthopaedics · 2023Article
- Identification of early response to hypertonic dextrose prolotherapy markers in knee osteoarthritis patients by an inflammation-related cytokine array.Journal of the Chinese Medical Association : JCMA · 2022Article
- Association of anti-thyroid antibodies with radiographic knee osteoarthritis and chondrocalcinosis: a NHANES III study.Therapeutic advances in musculoskeletal disease · 2021Article
- Hypothyroidism Increases 90-Day Complications and Costs Following Primary Total Knee Arthroplasty.The Journal of arthroplasty · 2018Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo study whether thyroid function was associated with risk of hip or knee replacement due to primary osteoarthritis.
methodsIn a prospective cohort study, data from the second and third survey of the Nord-Trøndelag Health Study were linked to the Norwegian Arthroplasty Register in order to identify total hip or knee replacement as a result of primary osteoarthritis.
resultsAmong 37 891 participants without previously known thyroid disease we recorded 978 total hip replacements (THRs) and 538 total knee replacements (TKRs) during a median follow-up time of 15.7 years. The analyses were adjusted for sex, age, BMI (body mass index), smoking, physical activity and diabetes. We did not find any association between TSH (thyroid stimulating hormone) and THR or TKR due to osteoarthritis. Neither were changes in TSH over time, or overt hypo- or hyperthyroidism, associated with incidence of THR or TKR.
conclusionNo association was found between thyroid function and hip or knee joint replacement due to osteoarthritis.
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Registered trials
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