SynthesisBMC medical genetics2017
Association of 4p14 and 6q27 variation with Graves disease: a case-control study and a meta-analysis of available evidence.
Synthesis in BMC medical genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors at 6 institutions in 1 country.
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Abstract
backgroundThe etiology of the Graves' disease (GD) is largely unknown. However, genetic factors are believed to play a major role. A recent genome-wide association study in a Han Chinese sample collection revealed two new Graves' disease (GD) risk loci within chromosome band 4p14 and 6q27. In this study, we aimed to investigate these associations with Weifang Han Chinese population of Shandong province and perform a meta-analysis of associations with GD.
methodsA case-control study was conducted to investigate association of variation within 4p14 and 6q27 to GD susceptibility in Weifang Han Chinese population of Shandong province. SNP rs6832151 at chromosome 4p14 and SNP rs9355610 at chromosome 6q27 was selected for genotyping in 2,382 GD patients and 3,092 unrelated controls. SNP genotyping was performed using TaqMan Real-time PCR technique assays on ABI7900 platform. A meta-analysis was performed with the data obtained in the current sample-set and those available from prior studies.
resultsAssociation analysis revealed both rs6832151 located in 4p14 (odds ratio (OR) = 1.27, P
conclusionsOur findings showed that chromosome 4p14 and 6q27 variants were associated with Graves' disease in Weifang Han Chinese population of Shandong province.
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