ArticleBMC musculoskeletal disorders2017
T1rho and T2 relaxation times of the normal adult knee meniscus at 3T: analysis of zonal differences.
Article in BMC musculoskeletal disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Pooled it
- Internal-Control-Normalized T2 Mapping of Meniscal Abnormalities on a Cartilage MRI Protocol: An Exploratory Retrospective Study.Diagnostics (Basel, Switzerland) · 2026Article
- Grading knee cartilage degeneration and meniscal injury with combined ACS-accelerated T1ρ and T2 mapping.BMC medical imaging · 2026Article
- Recent topics in musculoskeletal imaging focused on clinical applications of AI: How should radiologists approach and use AI?La Radiologia medica · 2025Review
- Periodical assessment of four horns of knee meniscus using MR T2 mapping imaging in volunteers before and after amateur marathons.Scientific reports · 2022Article
- TSkeletal radiology · 2022Article
- Six-Month Outcomes of Clinically Relevant Meniscal Injury in a Large-Animal Model.Orthopaedic journal of sports medicine · 2021Review
- A pilot study to assess the healing of meniscal tears in young adult goats.Scientific reports · 2021Article
- Synovial mesenchymal stem cells promote the meniscus repair in a novel pig meniscus injury model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Functional MRI Mapping of Human Meniscus Functionality and its Relation to Degeneration.Scientific reports · 2020Observational
- Biexponential TJournal of magnetic resonance imaging : JMRI · 2019Article
- T2 mapping of cartilage and menisci at 3T in healthy subjects with knee malalignment: initial experience.Skeletal radiology · 2019Article
- Ultra-high field magnetic resonance imaging parameter mapping in the posterior horn of ex vivo human menisci.Osteoarthritis and cartilage · 2019Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPrior studies describe histological and immunohistochemical differences in collagen and proteoglycan content in different meniscal zones. The aim of this study is to evaluate horizontal and vertical zonal differentiation of T1rho and T2 relaxation times of the entire meniscus from volunteers without symptom and imaging abnormality.
methodsTwenty volunteers age between 19 and 38 who have no knee-related clinical symptoms, and no history of prior knee surgeries were enrolled in this study. Two T1rho mapping (b-FFE T1rho and SPGR T1rho) and T2 mapping images were acquired with a 3.0-T MR scanner. Each meniscus was divided manually into superficial and deep zones for horizontal zonal analysis. The anterior and posterior horns of each meniscus were divided manually into white, red-white and red zones for vertical zonal analysis. Zonal differences of average relaxation times among each zone, and both inter- and intra-observer reproducibility were statistically analyzed.
resultsIn horizontal zonal analysis, T1rho relaxation times of the superficial zone tended to be higher than those of the deep zone, and this difference was statistically significant in the medial meniscal segments (84.3 ms vs 76.0 ms on b-FFE, p < 0.0001 and 96.5 ms vs 91.7 ms on SPGR, p = 0.004). In vertical zonal analysis, T1rho relaxation times of the white zone tended to be higher than those of the red zone, and this difference was statistically significant in the posterior horn of the medical meniscus (88.4 ms vs 77.1 ms on b-FFE, p < 0.001 and 104.9 ms vs 96.8 ms on SPGR, p =0.001). Likewise, T2 relaxation times of the superficial zone were significantly higher than those of the deep zone (80.4 ms vs 74.4 ms in the medial meniscus, p = 0.011). T2 relaxation times of the white zone were significantly higher than those of the red zone in the medial meniscus posterior horn (96.8 ms vs 84.3 ms, p < 0.001) and lateral meniscus anterior horn (104.6 ms vs 84.2 ms, p < 0.0001). Inter-class and intra-class correlation coefficients were excellent (>0.74) or good (0.60-0.74) in all meniscal segments on both horizontal and vertical zonal analysis, except for inter-class correlation coefficients of the lateral meniscus on SPGR. Compared with SPGR T1rho images, b-FFE T1rho images demonstrated more significant zonal differentiation with higher inter- and intra-observer reproducibility.
conclusionsThere are zonal differences in T1rho and T2 relaxation times of the normal meniscus.
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