Evidence map›Paper›PMID 28521805›Full record

ReviewOrphanet journal of rare diseases2017

Thalassemias in South Asia: clinical lessons learnt from Bangladesh.

Mohammad Sorowar Hossain, Enayetur Raheem, Tanvira Afroze Sultana, Shameema Ferdous, Nusrat Nahar, Sazia Islam, Mohammad Arifuzzaman, Mohammad Abdur Razzaque, Rabiul Alam, Sonia Aziz and 3 more

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Orphanet journal of rare diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06098014 phase1completednot on this mapstarted 2023, after this paper: background citation

Safety & Efficacy of Thalidomide in Children With Transfusion Dependent Thalassemia: a Quasi Randomized Control Trial in a Tertiary Care Hospital in Bangladesh

TypeinterventionalSponsorBangabandhu Sheikh Mujib Medical University, Dhaka, BangladeshRan2023 to 2024Enrolled60ConditionsTransfusion-dependent ThalassemiaArmsThalidomide Capsules, Placebo
NCT06299670 phase4completednot on this mapstarted 2023, after this paper: background citation

Efficacy of Combination of Hdroxyurea and Thalidomide Over Either Hydroxyurea or Thalidomide Alone in the Treatment of Transfusion Dependent Thalassemia in Children: A Quasi-Randomised Clinical Trial

TypeinterventionalSponsorBangabandhu Sheikh Mujib Medical University, Dhaka, BangladeshRan2023 to 2026Enrolled90ConditionsTransfusion-dependent ThalassemiaArmsThalidomide, Hydroxy Urea, Combinations
3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Trial
  2. The epidemiology of thalassaemia syndromes in Southeast Asia.The Lancet regional health. Southeast Asia · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Review
  10. Article
  11. Assessment of Cardiac, Hepatic and Pancreatic Iron Overload in Transfusion Dependent Thalassemia Patients Using T2* Magnetic Resonance Imaging.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025
    Article
  12. Article
  13. Article
  14. Global Globin Network and adopting genomic variant database requirements for thalassemia.Database : the journal of biological databases and curation · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mohammad Sorowar HossainBiomedical Research Foundation, House #7, Apartment# 1A, Road# 1/B, Banani, Chairman Bari, Dhaka-1213, Bangladesh. sorowar.hossain@brfbd.org.
Enayetur RaheemBiomedical Research Foundation, House #7, Apartment# 1A, Road# 1/B, Banani, Chairman Bari, Dhaka-1213, Bangladesh.
Tanvira Afroze SultanaBiomedical Research Foundation, House #7, Apartment# 1A, Road# 1/B, Banani, Chairman Bari, Dhaka-1213, Bangladesh.
Shameema FerdousBiomedical Research Foundation, House #7, Apartment# 1A, Road# 1/B, Banani, Chairman Bari, Dhaka-1213, Bangladesh.
Nusrat NaharThalassemia Foundation Hospital, Dhaka, Bangladesh.
Sazia IslamTrinity College, Dublin, Ireland.
Mohammad ArifuzzamanBiomedical Research Foundation, House #7, Apartment# 1A, Road# 1/B, Banani, Chairman Bari, Dhaka-1213, Bangladesh.
Mohammad Abdur RazzaqueBiomedical Research Foundation, House #7, Apartment# 1A, Road# 1/B, Banani, Chairman Bari, Dhaka-1213, Bangladesh.
Rabiul AlamBiomedical Research Foundation, House #7, Apartment# 1A, Road# 1/B, Banani, Chairman Bari, Dhaka-1213, Bangladesh.
Sonia AzizDepartment of Economics & Business, Moravian College, Bethlehem, USA.
Hazera KhatunSaint Michael's Medical Center, Newark, NJ, USA.
Abdur RahimThalassemia Foundation Hospital, Dhaka, Bangladesh.
Manzur MorshedThalassemia Foundation Hospital, Dhaka, Bangladesh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thalassemias are emerging as a global public health concern. Due to remarkable success in the reduction of childhood mortality by controlling infectious diseases in developing countries, thalassemias are likely to be a major public health concern in the coming decades in South Asia. Despite the fact that Bangladesh lies in the world's thalassemia belt, the information on different aspects (epidemiology, clinical course, mortality, complications and treatment outcomes) of thalassemias is lacking. In this comprehensive review, the aim is to to depict the epidemiological aspects of thalassemias, mutation profile and current treatment and management practices in the country by sharing the experience of dealing with 1178 cases over 2009-2014 time periods in a specialized thalassemia treatment centre. We have also discussed the preventative strategies of thalassemias from the context of Bangladesh which could be effective for other developing countries.

Indexed as

AnimalsAsiaBangladeshbeta-ThalassemiaHemoglobinopathiesHumansMutationThalassemiaBangladeshBeta thalassemiaBeta thalassemia majorHbE beta thalassemiaHemoglobinopathiesNon-transfusion dependent thalassemiaThalassemia traitTransfusion dependent thalassemia

Identifiers

PMID28521805
PMCPMC5437604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.